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一例迟发性弥漫性轴索损伤的病例报告。

A case report on delayed: onset diffuse axonal injury.

作者信息

Adhikari Sonu, Raut Rupesh, Shrestha Dinuj, Shah Susmita, Bhattarai Ayam, Bista Prakash

机构信息

Department of Neurosurgery, Patan Academy of Health Science, Lalitpur, Nepal.

Birtamode Nagar Hospital, Birtamode, Nepal.

出版信息

Ann Med Surg (Lond). 2025 May 30;87(7):4655-4660. doi: 10.1097/MS9.0000000000003447. eCollection 2025 Jul.

Abstract

INTRODUCTION

Diffuse axonal injury (DAI) is characterized by immediate loss of consciousness lasting for more than 6 hours following traumatic head injury. It can be classified into three grades based on the duration of coma, severity, and the presence of radiological or histological evidence of lesions in various parts of the brain.

CASE PRESENTATION

In this report, we present a case of a 20-year-old non-alcoholic male sustaining a head injury following a fall from a swing. On presentation, his Glasgow Coma Scale (GCS) was 15, which greatly fluctuated between 10 and 15 during hospitalization. MRI of the brain was suggestive of grade three DAI. Unusually, he went into a coma after 50 hours of admission. He was subsequently intubated and managed conservatively at our facility.

CLINICAL DISCUSSION

DAI is one of the major causes of disability, post-traumatic coma, and persistent vegetative state following traumatic events. It is typically marked by an immediate loss of consciousness, resulting in only a few cases being recognized with delayed presentation. This case report exemplifies a unique and noteworthy instance of delayed onset DAI.

CONCLUSION

DAI is often associated with traumatic brain injury (TBI), and it should always be suspected when the clinical presentation of the patient is significantly more severe than the initial computed tomography (CT) head findings. Maintaining a strong clinical suspicion and considering the possibility of unusual findings can facilitate prompt diagnosis and management of patients with DAI in clinical practice.

摘要

引言

弥漫性轴索损伤(DAI)的特征是创伤性脑损伤后立即出现意识丧失,持续超过6小时。根据昏迷持续时间、严重程度以及大脑各部位病变的影像学或组织学证据,可将其分为三个等级。

病例报告

在本报告中,我们呈现了一例20岁非酒精性男性患者,其从秋千上跌落致头部受伤。就诊时,他的格拉斯哥昏迷量表(GCS)评分为15分,住院期间在10至15分之间大幅波动。脑部MRI提示为三级DAI。不同寻常的是,入院50小时后他陷入昏迷。随后在我们的医疗机构进行了气管插管并采取保守治疗。

临床讨论

DAI是创伤事件后导致残疾、创伤后昏迷和持续性植物状态的主要原因之一。其典型表现为立即出现意识丧失,因此只有少数病例表现为延迟发作。本病例报告例证了延迟发作DAI这一独特且值得注意的情况。

结论

DAI常与创伤性脑损伤(TBI)相关,当患者的临床表现明显比最初的头颅计算机断层扫描(CT)结果严重时,应始终怀疑存在DAI。在临床实践中,保持高度的临床怀疑并考虑异常发现的可能性有助于对DAI患者进行及时诊断和管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4310/12369761/8edf5220f551/ms9-87-4655-g001.jpg

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