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气候变化的神经学后果:新兴挑战及对大脑健康潜在影响的综述

Neurological consequences of climate change: a review of emerging challenges and potential impacts on brain health.

作者信息

Jilanee Syed Daniyal Ahmed, Saeed Muhammad, Ahsan Muhammad Umar, Farooq Muhammad Usman, Ahmed Somaiya, Shahid Hiba, Sharif Sajawal

机构信息

Liaquat National Hospital and Medical College, Karachi, Pakistan.

D.G. Khan Medical College, Dera Ghazi Khan, Pakistan.

出版信息

Ann Med Surg (Lond). 2025 May 26;87(7):4209-4221. doi: 10.1097/MS9.0000000000003425. eCollection 2025 Jul.

Abstract

Climate change causes significant challenges to the neurological system due to both gradual and immediate environmental changes. This paper explores the various issues facing by the brain because of climate change, such as increased cases of heat-related diseases, neuroinflammation, oxidative stress, altered patterns of diseases, and phenomena associated with very severe weather conditions. A comprehensive literature search was conducted. This paper demonstrates evidences, linking climate-related factors (air pollution, heat exposure, and vector-borne diseases) to neuroinflammation and oxidative stress, the major contributors to neurodegenerative diseases. Additionally, it addresses targeted interventions to mitigate health risks, particularly among vulnerable groups such as the elderly and children. Moreover, it was noticed how climate change affects mental health in terms of anxiety and depression. Chronic stress disorders should, therefore, be considered during mental health interventions for climate adaptation. The study highly emphasizes collaborative research networks and open-access data repositories while advocating for interdisciplinary approaches and policy support to deepen our knowledge and lessen neurological effects related to climatic variability. This review highlights the importance of multidisciplinary research and policy interventions to mitigate these risks and protect global neurological health.

摘要

由于渐进和即时的环境变化,气候变化给神经系统带来了重大挑战。本文探讨了气候变化给大脑带来的各种问题,如与热相关疾病病例增加、神经炎症、氧化应激、疾病模式改变以及与极端恶劣天气状况相关的现象。进行了全面的文献检索。本文展示了将与气候相关的因素(空气污染、热暴露和媒介传播疾病)与神经炎症和氧化应激联系起来的证据,而神经炎症和氧化应激是神经退行性疾病的主要促成因素。此外,它还阐述了针对减轻健康风险的有针对性的干预措施,特别是在老年人和儿童等弱势群体中。此外,还注意到气候变化在焦虑和抑郁方面如何影响心理健康。因此,在适应气候的心理健康干预中应考虑慢性应激障碍。该研究高度强调合作研究网络和开放获取的数据存储库,同时倡导跨学科方法和政策支持,以加深我们的认识并减轻与气候变异性相关的神经学影响。这篇综述强调了多学科研究和政策干预对于减轻这些风险以及保护全球神经健康的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e77/12369783/3b7734be656f/ms9-87-4209-g001.jpg

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