Dhungana Sanjay, Paudyal Anish, Bhatta Sachin, Karki Sphurna, Kharel Manish
Nepal Medical College and Teaching Hospital, Kathmandu University, Jorpati, Nepal.
Department of Pathology, Nepal Medical College and Teaching Hospital, Kathmandu University, Jorpati, Kathmandu, Nepal.
Ann Med Surg (Lond). 2025 May 20;87(7):4614-4617. doi: 10.1097/MS9.0000000000003403. eCollection 2025 Jul.
Porokeratosis is a rare keratinization disorder marked by atrophic patches with a distinct hyperkeratotic border known as a cornoid lamella. Genital porokeratosis (GP), especially involving the penis, is extremely uncommon, with only a handful of cases reported worldwide. This case report describes the first instance of penile porokeratosis from Nepal, highlighting its rarity and clinical presentation.
A 22-year-old male presented with a 3 × 3 cm annular plaque on the shaft of his penis, which had been asymptomatic for a year. Histopathology confirmed the diagnosis of porokeratosis, and tests for sexually transmitted infections were negative. Following a single session of cryotherapy, the patient was counseled about the benign nature of the lesion. Regular follow-ups were scheduled every 4 weeks for additional cryotherapy and to monitor for any potential malignant change.
GP is a rare condition, potentially triggered by environmental factors like heat and friction. Diagnosis can be challenging due to its similarity to other dermatoses, making histopathology essential. Although other forms of porokeratosis carry a risk of malignancy, there are no known cases of GP progressing to cancer.
Penile porokeratosis should be considered in the differential diagnosis of persistent genital lesions. A biopsy is crucial for accurate diagnosis, as misdiagnosis can delay appropriate treatment. Further studies are needed to better understand this rare disease, including its incidence, pathophysiology, and risk of malignant transformation.
汗孔角化症是一种罕见的角化异常性疾病，其特征为萎缩性斑块伴有一条称为鸡眼样板的明显角化过度边界。生殖器汗孔角化症（GP），尤其是累及阴茎的情况极为罕见，全球仅报道了少数病例。本病例报告描述了尼泊尔首例阴茎汗孔角化症，突出了其罕见性和临床表现。
一名22岁男性，阴茎体部出现一个3×3厘米的环状斑块，已无症状一年。组织病理学确诊为汗孔角化症，性传播感染检测为阴性。单次冷冻治疗后，向患者说明了病变的良性性质。每4周安排定期随访，进行额外的冷冻治疗并监测是否有任何潜在的恶性变化。
GP是一种罕见疾病，可能由热和摩擦等环境因素引发。由于其与其他皮肤病相似，诊断可能具有挑战性，因此组织病理学至关重要。虽然其他形式的汗孔角化症有恶变风险，但尚无已知的GP进展为癌症的病例。
在持续性生殖器病变的鉴别诊断中应考虑阴茎汗孔角化症。活检对于准确诊断至关重要，因为误诊可能会延迟适当的治疗。需要进一步研究以更好地了解这种罕见疾病，包括其发病率、病理生理学和恶变风险。
