Prachi Prachi, Aiyer Hema Malini, Sharma Gaurav, Shrivastav Ashish Kumar
Department of Anatomic Pathology, Dharamshila Narayana Superspeciality Hospital and Research Centre, Vasundhara Enclave, New Delhi, India.
Department of Neurosurgery and Neurointervention, Dharamshila Narayana Superspeciality Hospital and Research Centre, Vasundhara Enclave, New Delhi, India.
Asian J Neurosurg. 2025 Jun 4;20(3):660-663. doi: 10.1055/s-0045-1809329. eCollection 2025 Sep.
Primary intracranial melanomas are an extremely rare entity and are a diagnosis of exclusion. Malignant melanoma represents the third most common site for cerebral metastasis. We hereby narrate a comprehensive and detailed case of metastatic intracranial melanomas with BRAF mutation, which later on had an extensive systemic spread. The imaging differentials include metastasis, intracranial hemorrhage, or granuloma. The final and definitive diagnosis was attained by detailed clinical, histological, and immunohistochemical evaluation as metastatic malignant pigmented tumor consistent with intracranial melanoma.
原发性颅内黑色素瘤是一种极其罕见的疾病，属于排除性诊断。恶性黑色素瘤是脑转移的第三大常见部位。我们在此叙述一例伴有BRAF突变的转移性颅内黑色素瘤的全面且详细的病例，该病例随后出现了广泛的全身扩散。影像学鉴别诊断包括转移瘤、颅内出血或肉芽肿。最终通过详细的临床、组织学和免疫组化评估确诊为与颅内黑色素瘤一致的转移性恶性色素性肿瘤。
