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分子网络引导下从……中分离抗炎异落叶松脂素和裂环异落叶松脂素型木脂素

Molecular Networking-Guided Isolation of Anti-Inflammatory Isolariciresinol and Seco-Isolariciresinol Type Lignans from.

作者信息

Kim Jun Gu, Han Jae Sang, Cho Yong Beom, Lee Dongho, Lee Mi Kyeong, Hwang Bang Yeon

机构信息

College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.

Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

出版信息

ACS Omega. 2025 Aug 7;10(32):36652-36661. doi: 10.1021/acsomega.5c05794. eCollection 2025 Aug 19.

DOI:10.1021/acsomega.5c05794
PMID:40852275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12368658/
Abstract

A comparative analysis of UPLC-DAD and MS chromatograms revealed distinct chemical profiles between the methanolic extracts of the branch and cortex of . MS/MS-based molecular networking further identified unique molecular features present in the branch extract, which facilitated the targeted isolation of five previously undescribed lignan derivatives. The structures of these compounds were elucidated using 1D and 2D NMR spectroscopy, along with high-resolution mass spectrometry (HRMS). The anti-inflammatory potential of the isolated compounds was evaluated by measuring the inhibition LPS-induced nitric oxide (NO) production in RAW 264.7 macrophage cells. Notably, compounds exhibited significant NO inhibitory activity, with IC values of 3.7 and 7.4 μM.

摘要

超高效液相色谱-二极管阵列检测法（UPLC-DAD）和质谱色谱图的对比分析显示，[植物名称]枝条和树皮的甲醇提取物之间存在明显的化学特征。基于串联质谱（MS/MS）的分子网络进一步鉴定出枝条提取物中存在的独特分子特征，这有助于靶向分离出5种先前未描述的木脂素衍生物。使用一维和二维核磁共振光谱（NMR）以及高分辨率质谱（HRMS）阐明了这些化合物的结构。通过测量脂多糖（LPS）诱导的RAW 264.7巨噬细胞中一氧化氮（NO）的产生，评估了分离出的化合物的抗炎潜力。值得注意的是，化合物表现出显著的NO抑制活性，IC值分别为3.7和7.4 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/3a294e4497be/ao5c05794_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/a6d1a50ecd79/ao5c05794_0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/de0be01293e5/ao5c05794_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/5ae6a9140f93/ao5c05794_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/ac670a3910c4/ao5c05794_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/e1b0da8acbe8/ao5c05794_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/eb5bba673d4a/ao5c05794_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/7f1dcb454a4c/ao5c05794_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/3a294e4497be/ao5c05794_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/a6d1a50ecd79/ao5c05794_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/c0d146fd9d8e/ao5c05794_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/de0be01293e5/ao5c05794_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/5ae6a9140f93/ao5c05794_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/ac670a3910c4/ao5c05794_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/e1b0da8acbe8/ao5c05794_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/eb5bba673d4a/ao5c05794_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/7f1dcb454a4c/ao5c05794_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1af/12368658/3a294e4497be/ao5c05794_0009.jpg

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