从 中提取的木脂素糖苷和黄酮苷及其生物评价。
Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of and Their Biological Evaluations.
机构信息
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
出版信息
Molecules. 2018 Aug 1;23(8):1920. doi: 10.3390/molecules23081920.
(Fabaceae), known as Chinese bushclover, has been used in traditional medicines for the treatment of diseases including diabetes, hematuria, and insomnia. As part of a continuing search for bioactive constituents from Korean medicinal plant sources, phytochemical analysis of the aerial portion of led to the isolation of two new lignan glycosides (,) along with three known lignan glycosides (⁻) and nine known flavonoid glycosides (⁻). Numerous analysis techniques, including 1D and 2D NMR spectroscopy, CD spectroscopy, HR-MS, and chemical reactions, were utilized for structural elucidation of the new compounds (,). The isolated compounds were evaluated for their applicability in medicinal use using cell-based assays. Compounds and ⁻ exhibited weak cytotoxicity against four human breast cancer cell lines (Bt549, MCF7, MDA-MB-231, and HCC70) (IC < 30.0 μM). However, none of the isolated compounds showed significant antiviral activity against PR8, HRV1B, or CVB3. In addition, compound produced fewer lipid droplets in Oil Red O staining of mouse mesenchymal stem cells compared to the untreated negative control without altering the amount of alkaline phosphatase staining.
槐属（Fabaceae），俗称中国山蚂蝗，在传统医学中被用于治疗包括糖尿病、血尿和失眠在内的疾病。作为从韩国药用植物资源中寻找生物活性成分的持续研究的一部分，对地上部分的化学成分分析导致分离出两种新的木脂素糖苷（，），以及三种已知的木脂素糖苷（⁻）和九种已知的黄酮苷（⁻）。利用包括 1D 和 2D NMR 光谱、CD 光谱、高分辨质谱和化学反应在内的多种分析技术，对新化合物（，）进行了结构阐明。利用基于细胞的测定法评估了分离出的化合物在药用方面的适用性。化合物和 ⁻ 对四种人乳腺癌细胞系（Bt549、MCF7、MDA-MB-231 和 HCC70）（IC < 30.0 μM）表现出微弱的细胞毒性。然而，分离出的化合物均对 PR8、HRV1B 或 CVB3 没有显著的抗病毒活性。此外，与未经处理的阴性对照相比，化合物 在用油红 O 染色的小鼠间充质干细胞中产生的脂滴更少，而碱性磷酸酶染色的量没有改变。
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