Yang Hanhang, Li Ruowen, Ma Hao, Tian Lingtao, Yan Jingchen, Chen Gang, Zhang Zhifeng
Faculty of Chinses Medicine, State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Padre Tomas Pereira, Taipa, Macau 999078, China.
Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangdong 510006, China.
ACS Omega. 2025 Aug 8;10(32):35540-35550. doi: 10.1021/acsomega.5c00059. eCollection 2025 Aug 19.
This study developed a stable Forsythia essential oil (FEO) microemulsion (FEO-ME) using a self-microemulsifying drug delivery system (SMEDDS). The FEO-ME effectively reduced the volatility of essential oil and inhibited bioactive component degradation. By constructing pseudoternary phase diagrams, the optimal formulation was identified, utilizing the surfactant EL-40 and cosurfactant ethanol. The resulting microemulsion exhibited an average droplet size of 21.58 nm and an encapsulation efficiency of 85.6%. FEO-ME demonstrated excellent storage stability over 15 days, with minimal changes in droplet size and polydispersity index (PDI), ensuring long-term reliability. Additionally, antibacterial tests revealed enhanced efficacy against compared to raw FEO. These findings highlight the potential of FEO-ME to enhance the bioactivity, stability, and applicability of essential oils with promising applications in food preservation, pharmaceuticals, and other industries.
本研究采用自微乳化给药系统（SMEDDS）开发了一种稳定的连翘精油（FEO）微乳液（FEO-ME）。FEO-ME有效降低了精油的挥发性并抑制了生物活性成分的降解。通过构建伪三元相图，利用表面活性剂EL-40和助表面活性剂乙醇确定了最佳配方。所得微乳液的平均粒径为21.58 nm，包封率为85.6%。FEO-ME在15天内表现出优异的储存稳定性，粒径和多分散指数（PDI）变化极小，确保了长期可靠性。此外，抗菌测试表明，与未加工的FEO相比，其功效有所增强。这些发现突出了FEO-ME在提高精油生物活性、稳定性和适用性方面的潜力，在食品保鲜、制药和其他行业具有广阔的应用前景。
