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普拉卡什项目:视觉研究中基础科学与社会服务的融合

Project Prakash: Merging Basic Science and Societal Service in Vision Research.

作者信息

Gilad-Gutnick Sharon

机构信息

Department of Brain and Cognitive Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States.

出版信息

Policy Insights Behav Brain Sci. 2023 Oct;10(2):287-295. doi: 10.1177/23727322231196867. Epub 2023 Oct 26.

DOI:10.1177/23727322231196867
PMID:40852320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12369547/
Abstract

For nearly 20 years, Prakash has created a humanitarian-scientific synergy by treating congenitally blind children in rural India, then following their visual development to understand how the human brain learns to see. From solving a 300-year-old conundrum to deconstructing the "critical window" of neuroplasticity, Prakash has led to new ways of thinking about development. Unfortunately, many children suffering from treatable congenital blindness around the world remain untreated due to a persistent belief that improvements are not possible past a "critical age" of 5-7 years old. Here, a review of the data identifies an urgent need to engage with stakeholders across the global medical community to disseminate Prakash's findings and overturn these entrenched dogmas. Toward that end, recent partnerships with eye-health organizations expand the reach of this approach and cultivate a cohesive global network. Prakash exemplifies both evidence-based intervention and intervention-based scientific discovery.

摘要

近20年来,普拉卡什通过治疗印度农村的先天性失明儿童,创造了一种人道主义与科学的协同效应,然后追踪他们的视力发育情况,以了解人类大脑是如何学会看见的。从解决一个300年的难题到解构神经可塑性的“关键窗口期”,普拉卡什带来了关于发育的新思维方式。不幸的是,由于人们一直认为,在5至7岁的“关键年龄”之后视力就无法改善,世界各地许多患有可治疗先天性失明的儿童仍然得不到治疗。在此,对数据的回顾表明,迫切需要与全球医学界的利益相关者合作,传播普拉卡什的研究结果,并推翻这些根深蒂固的教条。为此,最近与眼健康组织的合作扩大了这种方法的影响力,并培育了一个有凝聚力的全球网络。普拉卡什体现了基于证据的干预和基于干预的科学发现。

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本文引用的文献

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White matter plasticity following cataract surgery in congenitally blind patients.先天性盲人白内障手术后的白质可塑性。
Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2207025120. doi: 10.1073/pnas.2207025120. Epub 2023 May 1.
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Learning to see after early and extended blindness: A scoping review.早期及长期失明后重见光明:一项范围综述
Front Psychol. 2022 Oct 27;13:954328. doi: 10.3389/fpsyg.2022.954328. eCollection 2022.
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Infant color perception: Insight into perceptual development.婴儿的颜色感知:对感知发展的洞察。
Child Dev Perspect. 2022 Jun;16(2):90-95. doi: 10.1111/cdep.12447. Epub 2022 Mar 21.
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Head turning is an effective cue for gaze following: Evidence from newly sighted individuals, school children and adults.头部转动是注视跟随的有效线索:来自新视力者、学童和成年人的证据。
Neuropsychologia. 2022 Sep 9;174:108330. doi: 10.1016/j.neuropsychologia.2022.108330. Epub 2022 Jul 14.
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Human (but not animal) motion can be recognized at first sight - After treatment for congenital blindness.先天性失明治疗后,人(而非动物)的动作可以一眼识别。
Neuropsychologia. 2022 Sep 9;174:108307. doi: 10.1016/j.neuropsychologia.2022.108307. Epub 2022 Jun 22.
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The Pediatric Eye Health Challenge Beyond 2020.《2020 年后的儿童眼健康挑战》。
Am J Trop Med Hyg. 2021 Jul 12;105(3):555-556. doi: 10.4269/ajtmh.21-0058.
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Color vision in sight recovery individuals.视功能恢复者的色觉
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