Wang Li-Zhen, Li Wen-Qiang, Li Yao, Li Xiao-Yan, Ju Shuai
Department of Nephrology, Jinshan Hospital of Fudan University, Shanghai, China.
Department of Vascular and Wound Center, Jinshan Hospital of Fudan University, Shanghai, China.
Front Med (Lausanne). 2025 Aug 7;12:1620649. doi: 10.3389/fmed.2025.1620649. eCollection 2025.
Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition with significant implications for liver and cardiovascular health. Alterations in portal hemodynamics due to hepatic steatosis remain poorly understood.
This study aims to explore the correlation between liver fat fraction (FF) and portal hemodynamics in NAFLD patients.
A retrospective observational study was conducted involving 125 clinical suspected NAFLD patients. Liver FF was measured using MRI proton density fat fraction (PDFF). MRI 4D Flow was used to assess portal hemodynamic parameters, including flow velocity, flow volume, and portal area. Statistical analyses examined the relationships between liver FF and hemodynamic parameters.
Liver FF was negatively associated with portal peak flow velocity ( = -0.33) and portal mean flow velocity ( = -0.49), but was positively correlated with portal area ( = 0.39). No correlation was found in liver FF and portal flow volume ( = 0.114). Portal peak velocity demonstrated AUCs of 0.69 (95% CI: 0.57-0.82) for differentiating G0 from G1-3, 0.70 (95% CI: 0.60-0.79) for G0-1 versus G2-3, and 0.57 (95% CI: 0.44-0.69) for G0-2 versus G3. Portal mean velocity demonstrated AUCs of 0.84 (95% CI: 0.76-0.92) for differentiating G0 from G1-3, 0.78 (95% CI: 0.69-0.86) for G0-1 versus G2-3, and 0.70 (95% CI: 0.60-0.79) for G0-2 versus G3. Portal area demonstrated AUCs of 0.79 (95% CI: 0.70-0.78) for G0 versus G1-3, 0.78 (95% CI: 0.48-0.92) for G0-1 versus G2-3, and 0.84 (95% CI: 0.76-0.92) for G0-2 versus G3.
Liver FF is a significant determinant of portal hemodynamics in NAFLD patients. These findings underscore the potential of integrating liver FF and portal hemodynamic assessments into clinical practice for detection and management of NAFLD progression.
非酒精性脂肪性肝病（NAFLD）是一种常见疾病，对肝脏和心血管健康有重大影响。肝脂肪变性导致的门静脉血流动力学改变仍知之甚少。
本研究旨在探讨NAFLD患者肝脏脂肪分数（FF）与门静脉血流动力学之间的相关性。
进行了一项回顾性观察研究，纳入125例临床疑似NAFLD患者。使用MRI质子密度脂肪分数（PDFF）测量肝脏FF。采用MRI 4D Flow评估门静脉血流动力学参数，包括流速、流量和门静脉面积。通过统计分析研究肝脏FF与血流动力学参数之间的关系。
肝脏FF与门静脉峰值流速（=-0.33）和门静脉平均流速（=-0.49）呈负相关，但与门静脉面积呈正相关（=0.39）。未发现肝脏FF与门静脉流量之间存在相关性（=0.114）。门静脉峰值流速在区分G0与G1-3时的AUC为0.69（95%CI：0.57-0.82），区分G0-1与G2-3时的AUC为0.70（95%CI：0.60-0.79），区分G0-2与G3时的AUC为0.57（95%CI：0.44-0.69）。门静脉平均流速在区分G0与G1-3时的AUC为0.84（95%CI：0.76-0.92），区分G0-1与G2-3时的AUC为0.78（95%CI：0.69-0.86），区分G0-2与G3时的AUC为0.70（95%CI：0.60-0.79）。门静脉面积在区分G0与G1-3时的AUC为0.79（95%CI：0.70-0.78），区分G0-1与G2-3时的AUC为0.78（95%CI：0.4-0.92），区分G0-2与G呈正相关（=肝脏FF与门静脉流量之间存在相关性（=0.114）。门静脉峰值流速在区分G0与G1-3时的AUC为0.69（95%CI：0.57-0.82），区分G0-1与G2-3时的AUC为0.70（95%CI：0.60-0.79），区分G0-2与G3时的AUC为0.57（95%CI：0.44-0.69）。门静脉平均流速在区分G0与G1-3时的AUC为0.84（95%CI：0.76-0.92），区分G0-1与G2-3时的AUC为0.78（95%CI：0.69-0.86），区分G0-2与G3时的AUC为0.70（95%CI：0.60-0.79）。门静脉面积在区分G0与G1-3时的AUC为0.79（95%CI：0.70-0.78），区分G0-1与G2-3时的AUC为0.78（95%CI：0.48-0.92），区分G0-2与G3时的AUC为0.84（95%CI：0.76-0.92）。
肝脏FF是NAFLD患者门静脉血流动力学的重要决定因素。这些发现强调了将肝脏FF和门静脉血流动力学评估整合到临床实践中以检测和管理NAFLD进展的潜力。 3时的AUC为0.84（95%CI：0.76-0.92）。
肝脏FF是NAFLD患者门静脉血流动力学的重要决定因素。这些发现强调了将肝脏FF和门静脉血流动力学评估整合到临床实践中以检测和管理NAFLD进展的潜力。
