Jiang Jiefeng, Guan Lyuxin, Gan Ziqin, Wu Zhili, Liang Xiaofeng, Zhang Zhiwen, Lyu Yansi, Liang Yunsheng
The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Dermatology Hospital, Southern Medical University, Guangzhou, China.
Front Med (Lausanne). 2025 Aug 7;12:1574896. doi: 10.3389/fmed.2025.1574896. eCollection 2025.
Psoriatic arthritis (PsA) has been closely associated with an elevated risk of cardiovascular disease (CVD). Nevertheless, the connection between Life's Crucial 9 (LC9), which serves as a holistic measure of cardiovascular health (CVH), and PsA remains insufficiently studied. This research aims to explore the potential relationship between LC9 and the prevalence of PsA.
To investigate the role of LC9 in PsA and explore its implications.
This study utilized a cross-sectional, population-based design, analyzing data from 7,531 U.S. participants aged 20 years or older, drawn from the 2005-2006 and 2009-2014 cycles of the National Health and Nutrition Examination Survey (NHANES). The LC9 score, which encompasses nine distinct components, was classified into three CVH categories: low, moderate, and high. To explore the association between LC9 scores and the prevalence of PsA, logistic regression models and restricted cubic splines were applied.
In the analyzed cohort of 7,531 individuals, participants with moderate or high CVH levels demonstrated a markedly reduced likelihood of developing PsA relative to those with low CVH. Additionally, a 10-point elevation in the LC9 score was associated with a 32% lower odds of having PsA. A notable interaction between LC9 and age was detected. Conversely, no meaningful link was found between LC9 and psoriasis without arthritis (PsC).
The LC9 score and its subcomponents are significantly negatively correlated with the risk of PsA. This suggests that adherence to the lifestyle defined by LC9 is associated with a lower prevalence of PsA.
银屑病关节炎（PsA）与心血管疾病（CVD）风险升高密切相关。然而，作为心血管健康（CVH）整体衡量指标的生命关键9项（LC9）与PsA之间的联系仍研究不足。本研究旨在探讨LC9与PsA患病率之间的潜在关系。
研究LC9在PsA中的作用并探讨其意义。
本研究采用基于人群的横断面设计，分析了来自2005 - 2006年和2009 - 2014年国家健康和营养检查调查（NHANES）的7531名20岁及以上美国参与者的数据。包含九个不同组成部分的LC9评分被分为三个CVH类别：低、中、高。为了探讨LC9评分与PsA患病率之间的关联，应用了逻辑回归模型和受限立方样条。
在分析的7531名个体队列中，CVH水平为中度或高度的参与者患PsA的可能性相对于CVH水平低的参与者显著降低。此外，LC9评分每升高10分，患PsA的几率降低32%。检测到LC9与年龄之间存在显著交互作用。相反，未发现LC9与无关节炎的银屑病（PsC）之间存在有意义的关联。
LC9评分及其子成分与PsA风险显著负相关。这表明坚持由LC9定义的生活方式与较低的PsA患病率相关。
