Zhang Junjie, Ren Ci, Qin Zihan, Zhu Ling, Jin Zhoufeng, Yan Yuanyuan, Pan Xinghe, Luan Lan
Department of Pathology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.
Department of Dermatological Surgery, Shenyang Seventh People's Hospital, Shenyang, China.
Front Med (Lausanne). 2024 Oct 10;11:1445288. doi: 10.3389/fmed.2024.1445288. eCollection 2024.
Psoriasis is closely associated with cardiovascular disease (CVD). However, the current evidence on the correlation between Life's Essential 8 and Psoriasis is insufficient. Our aim was to investigate the relationship between Life's Essential 8 (LE8), a measure of cardiovascular health (CVH), and psoriasis.
This study aimed to clarify the impact of Life's Essential 8 on Psoriasis and explore its implications.
This population-based cross-sectional study included 9,876 US adults aged 20 to 59 years from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2009-2014 cycles. The LE8 score comprises 8 metrics and was categorized into low, moderate, and high CVH. Logistic regression and restricted cubic splines (RCS) were used to assess the association between LE8 score and psoriasis.
Among the 9,876 participants, those with moderate and high CVH had higher risks of psoriasis compared to low CVH. Additionally, every 10-point increase in the LE8 score was associated with a 10% reduced risk of psoriasis. Interaction was observed between gender, age, education level, race/ethnicity, marital status, and PIR.
LE8 and its subscale scores were strongly negatively related to the risk of psoriasis. Encouraging optimal CVH levels may be advantageous in reducing the incidence of psoriasis.
银屑病与心血管疾病（CVD）密切相关。然而，目前关于生命必需8要素与银屑病之间相关性的证据不足。我们的目的是研究心血管健康（CVH）指标生命必需8要素（LE8）与银屑病之间的关系。
本研究旨在阐明生命必需8要素对银屑病的影响并探讨其意义。
这项基于人群的横断面研究纳入了来自2003 - 2006年和2009 - 2014年国家健康与营养检查调查（NHANES）的9876名20至59岁的美国成年人。LE8评分由8个指标组成，并被分为低、中、高CVH类别。采用逻辑回归和受限立方样条（RCS）来评估LE8评分与银屑病之间的关联。
在9876名参与者中，与低CVH者相比，中、高CVH者患银屑病的风险更高。此外，LE8评分每增加10分，患银屑病的风险降低10%。在性别、年龄、教育水平、种族/民族、婚姻状况和贫困收入比（PIR）之间观察到了交互作用。
LE8及其子量表评分与银屑病风险呈强烈负相关。鼓励达到最佳CVH水平可能有利于降低银屑病的发病率。
