Pearce S, Sufi S B, Donaldson A, Jeffcoate S L
Contraception. 1985 Sep;32(3):275-81. doi: 10.1016/0010-7824(85)90051-4.
Gossypol, a phenolic compound that has been studied as a potential male contraceptive, has also been shown to inhibit basal and LH-stimulated testosterone production by mouse Leydig cells in vitro. This inhibition persists even when cells treated with gossypol are washed prior to reincubation with LH. While gossypol has been reported to be cytotoxic, its effect on steroidogenesis does not appear to be a consequence of cytotoxicity as there was no reduction in the number of viable cells after incubations in which inhibition of testosterone production was observed.
棉酚是一种已被研究作为潜在男性避孕药的酚类化合物，体外实验还表明它能抑制小鼠睾丸间质细胞基础状态下以及促黄体生成素（LH）刺激下的睾酮生成。即便在用LH重新孵育之前，将经棉酚处理的细胞洗涤过，这种抑制作用依然存在。虽然有报道称棉酚具有细胞毒性，但它对类固醇生成的影响似乎并非细胞毒性所致，因为在观察到睾酮生成受到抑制的孵育实验后，活细胞数量并未减少。
