Donaldson A, Sufi S B, Jeffcoate S L
Contraception. 1985 Feb;31(2):165-71. doi: 10.1016/0010-7824(85)90030-7.
Gossypol, a polyphenolic compound prepared from cotton seed, has potential uses as a male contraceptive. It inhibits spermatogenesis and sperm motility but has toxic side effects and furthermore may have effects on endocrine function though evidence for this is contradictory. In this study, gossypol had a dose-dependent inhibitory action on release of testosterone from dispersed mouse Leydig cells. Doses down to 20 microM and 10 microM significantly inhibited unstimulated and LH-stimulated release, respectively.
棉酚是一种从棉籽中提取的多酚类化合物，具有作为男性避孕药的潜在用途。它能抑制精子发生和精子活力，但具有毒副作用，此外，尽管关于其对内分泌功能影响的证据相互矛盾，但它可能会对内分泌功能产生影响。在本研究中，棉酚对分散的小鼠睾丸间质细胞释放睾酮具有剂量依赖性抑制作用。低至20微摩尔和10微摩尔的剂量分别显著抑制基础状态和促黄体生成素刺激状态下的睾酮释放。
