Organoarsonate- and Dimethylarsinate-Functionalized Hexamolybdates(V): A Multifaceted Study on Synthesis, Structural Dynamics, and Antibacterial Properties.

We report on the synthesis, functionalization, and structural characterization of 11 novel dimethylarsinate-functionalized arsenomolybdates(V), [RAsMoO(OH){AsO(CH)}] (R = HO, CH, CH, CH, 3,5-(HOOC)CH, 4-FCH, 4-FCCH, 4-FCOCH, 4-BrCH, and 4-NCH) and [AsMoO(OH){AsO(CH)}], featuring a reduced hexanuclear {MoO} core, peripherally coordinated by three dimethylarsinate ligands and centrally functionalized with diverse organoarsonate, arsenate, or arsenite groups, including carboxylated, fluorinated, brominated, and azido derivatives. Synthesized via a simple one-pot aqueous method, the compounds were thoroughly characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and elemental analysis in the solid state. Solution-phase stability was assessed by multinuclear (H, C, and F) nuclear magnetic resonance, while gas-phase behavior and fragmentation pathways were probed through electrospray ionization mass spectrometry, and tandem mass spectrometry (collision-induced dissociation). Antibacterial screening against , and three pathogenic bacterial strains , and revealed that three of the 11 polyanions exhibit moderate antibacterial activity. Additionally, the synthesis of 3,5-bis(carboxy)phenylarsonic acid, 3,5-(HOOC)CHAsOH, is reported here for the first time.