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MoMkt1，XPG/RAD2核酸酶家族的一员，在……中调节发育和致病性。

MoMkt1, a member of XPG/RAD2 nuclease family, regulates development and pathogenicity in .

作者信息

Li Na, Xiao Junlian, Yan Long, Kang Xiaoru, Wang Wenjuan, Chen Shen, Wu Weihuai, Zhang Shulin

机构信息

Anhui Province Key Laboratory of Crop Integrated Pest Management/College of Plant Protection, Anhui Agricultural University, Hefei, Peoples' Republic of China.

Guangdong Provincial Key Laboratory of High Technology for Plant Protection, Plant Protection Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, Peoples' Republic of China.

出版信息

Virulence. 2025 Dec;16(1):2546068. doi: 10.1080/21505594.2025.2546068. Epub 2025 Aug 25.

DOI:10.1080/21505594.2025.2546068
PMID:40852952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12380227/
Abstract

XPG/RAD2 nuclease family plays a crucial role in DNA damage repair to maintain genomic integrity. However, the biological function of Mkt1, a member of the XPG/RAD2 nuclease family, remains unclear in . In this study, we identified and characterized the biological functions of MoMkt1. Our results demonstrated that MoMkt1 is involved in hyphal growth, conidiation, normal appressorium development, degradation of glycogen and lipid droplets, cell wall stress and oxidative stress responses, and pathogenicity in . Additionally, MoMkt1 is required for scavenging host-derived reactive oxygen species (ROS) and responding to DNA replicative stress. Further investigation revealed that MoMkt1 interacts with the transcription factor IIH (TFIIH) core subunit MoTfb2. Overexpression (OE) of slightly affected the virulence of . Transcriptome data revealed that regulates metabolic pathways, cell wall, oxidation-reduction processes, and DNA repair. Our study provides insights into MoMkt1-mediated development and pathogenicity in .

摘要

XPG/RAD2核酸酶家族在维持基因组完整性的DNA损伤修复中起着关键作用。然而，XPG/RAD2核酸酶家族成员之一的Mkt1的生物学功能在……中仍不清楚。在本研究中，我们鉴定并表征了MoMkt1的生物学功能。我们的结果表明，MoMkt1参与菌丝生长、分生孢子形成、正常附着胞发育、糖原和脂滴降解、细胞壁应激和氧化应激反应以及在……中的致病性。此外，MoMkt1是清除宿主衍生的活性氧（ROS）和应对DNA复制应激所必需的。进一步研究表明，MoMkt1与转录因子IIH（TFIIH）核心亚基MoTfb2相互作用。……的过表达（OE）对……的毒力影响较小。转录组数据显示，……调节代谢途径、细胞壁、氧化还原过程和DNA修复。我们的研究为MoMkt1介导的……发育和致病性提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/f41ff383f8c1/KVIR_A_2546068_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/13498201383b/KVIR_A_2546068_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/213c5bf22133/KVIR_A_2546068_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/64510e7e6210/KVIR_A_2546068_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/17b448db77a6/KVIR_A_2546068_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/5e657b36747b/KVIR_A_2546068_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/be560bef1082/KVIR_A_2546068_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/558160c7036f/KVIR_A_2546068_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/05a6180b2678/KVIR_A_2546068_F0008_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/4531423dccdf/KVIR_A_2546068_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/dfa5f84d8001/KVIR_A_2546068_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/f41ff383f8c1/KVIR_A_2546068_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/13498201383b/KVIR_A_2546068_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/213c5bf22133/KVIR_A_2546068_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/64510e7e6210/KVIR_A_2546068_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/17b448db77a6/KVIR_A_2546068_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/5e657b36747b/KVIR_A_2546068_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/be560bef1082/KVIR_A_2546068_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/558160c7036f/KVIR_A_2546068_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/05a6180b2678/KVIR_A_2546068_F0008_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/4531423dccdf/KVIR_A_2546068_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/dfa5f84d8001/KVIR_A_2546068_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e377/12380227/f41ff383f8c1/KVIR_A_2546068_F0011_OC.jpg

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本文引用的文献

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A novel MAP kinase-interacting protein MoSmi1 regulates development and pathogenicity in Magnaporthe oryzae.一种新型的 MAP 激酶相互作用蛋白 MoSmi1 调控稻瘟病菌的发育和致病性。
Mol Plant Pathol. 2024 Jul;25(7):e13493. doi: 10.1111/mpp.13493.
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TFIIH central activity in nucleotide excision repair to prevent disease.
TFIIH 在核苷酸切除修复中的核心作用可预防疾病。
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FEN1 promotes cancer progression of cholangiocarcinoma by regulating the Wnt/β-catenin signaling pathway.FEN1 通过调控 Wnt/β-catenin 信号通路促进胆管癌的进展。
Dig Liver Dis. 2024 Apr;56(4):695-704. doi: 10.1016/j.dld.2023.08.050. Epub 2023 Aug 28.
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Roles of NRF2 in DNA damage repair.NRF2 在 DNA 损伤修复中的作用。
Cell Oncol (Dordr). 2023 Dec;46(6):1577-1593. doi: 10.1007/s13402-023-00834-5. Epub 2023 Jun 26.
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