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撤回声明:SENP2通过去SUMO化修饰转化生长因子-β受体I抑制膀胱癌细胞的上皮-间质转化

RETRACTION: SENP2 Suppresses Epithelial-Mesenchymal Transition of Bladder Cancer Cells Through deSUMOylation of TGF-βRI.

出版信息

Mol Carcinog. 2025 Aug 25. doi: 10.1002/mc.70038.

Abstract

M. Tan, D. Zhang, E. Zhang, D. Xu, Z. Liu, J. Qiu, Y. Fan, and B. Shen, "SENP2 Suppresses Epithelial-Mesenchymal Transition of Bladder Cancer Cells Through deSUMOylation of TGF-βRI," Molecular Carcinogenesis 56, no. 10 (2017): 2332-2341. https://doi.org/10.1002/mc.22687. The above article, published online on 02 June 2017, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by Wiley Periodicals LLC. A third party reported to the journal that image elements in Figure 2E of this article had been duplicated and manipulated from a previously published article by a different group of authors and reporting different experimental conditions (Mani et al. 2007 [https://doi.org/10.1073/pnas.0703900104]). Further investigation by the publisher confirmed this duplication and also detected additional duplications between the T24-Vector panel of Figure 5A and the first panel of Figure 5B, as well as duplication and rotation of image elements in the T24-SENP2 panel of Figure 5A and the third panel of Figure 5B. The authors responded to an inquiry by the publisher and stated that there were no issues of duplication between different articles and that the duplications in Figure 5 may have been caused by errors during image preparation. However, the authors were unable to provide original, unmodified data or images for the experiments reported. The retraction has been agreed to because of the duplication of images from another article, as well as duplication and rotation of images and image elements within the same article, which fundamentally compromises the reported conclusions. The authors have stated their consent to the retraction. The authors disagree with the retraction as they have stated they do not agree that image elements were duplicated in Figure 2E.

摘要

谭 M、张 D、张 E、徐 D、刘 Z、邱 J、范 Y 和沈 B,“SENP2 通过去泛素化 TGF-βRI 抑制膀胱癌细胞的上皮-间质转化”,《分子致癌作用》56 卷,第 10 期(2017 年):2332 - 2341。https://doi.org/10.1002/mc.22687。上述文章于 2017 年 6 月 2 日在线发表于威利在线图书馆(wileyonlinelibrary.com),已被威利期刊有限责任公司撤回。第三方告知该期刊,本文图 2E 中的图像元素是从另一组作者之前发表的一篇文章中复制并处理而来,且报道的实验条件不同(马尼等人,2007 年 [https://doi.org/10.1073/pnas.0703900104])。出版商的进一步调查证实了这种复制行为,还发现图 5A 的 T24 - 载体组与图 5B 的第一组之间存在额外的复制,以及图 5A 的 T24 - SENP2 组和图 5B 的第三组中的图像元素存在复制和旋转。作者回复了出版商的询问,并表示不同文章之间不存在复制问题,图 5 中的复制可能是图像准备过程中的错误所致。然而,作者无法为所报道的实验提供原始的、未修改的数据或图像。由于从另一篇文章复制图像,以及同一文章内图像和图像元素的复制与旋转,从根本上损害了所报道的结论,因此同意撤回。作者已声明同意撤回。作者不同意撤回,因为他们表示不同意图 2E 中存在图像元素复制的说法。

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