[胃癌、慢性萎缩性胃炎及正常对照中的姐妹染色单体交换]

[Sister chromatid exchange in gastric cancer, chronic atrophic gastritis and normal control].

作者信息

Zhou L

出版信息

Zhonghua Zhong Liu Za Zhi. 1985 Jul;7(4):257-9.

Abstract

The frequencies of sister chromatid exchange (SCE) in proven cases of 10 chronic atrophic gastritis and 9 gastric cancer were observed together with 10 cases of normal control. They were (1) chronic atrophic gastritis 6.98 +/- 0.89, (2) gastric cancer 7.49 +/- 0.42 and (3) normal control 5.89 +/- 0.57. Statistically, there was a very significant difference in the SCE frequencies between the gastric cancer and normal control groups (P less than 0.001) and a significant difference between the chronic atrophic gastritis and normal control groups (P less than 0.05). However, the difference between the gastric cancer and the chronic atrophic gastritis was not significant (P greater than 0.05). The similarity in the incidence of SCE may offer an evidence for the close relationship theory between gastric cancer and chronic atrophic gastritis.

摘要

对10例慢性萎缩性胃炎确诊病例、9例胃癌病例以及10例正常对照者的姐妹染色单体交换（SCE）频率进行了观察。结果如下：（1）慢性萎缩性胃炎为6.98±0.89；（2）胃癌为7.49±0.42；（3）正常对照为5.89±0.57。统计学分析显示，胃癌组与正常对照组的SCE频率差异非常显著（P＜0.001），慢性萎缩性胃炎组与正常对照组的SCE频率差异显著（P＜0.05）。然而，胃癌组与慢性萎缩性胃炎组之间的差异不显著（P＞0.05）。SCE发生率的相似性可能为胃癌与慢性萎缩性胃炎之间的密切关系理论提供了证据。