Hajikarimloo Bardia, Tos Salem M, Saha Abhishek, Mohammadzadeh Ibrahim, Mortezaei Ali, Hashemi Rana, Najari Dorsa, Ebrahimi Azin, Dmytriw Adam A, Habibi Mohammad Amin
Neurological Surgery, University of Virginia, Charlottesville, USA.
Department of Neuroradiology, Oxford University Hospitals NHS Foundation Trust, Nuffield Departments of Clinical Neurosciences and Surgical Sciences, University of Oxford, Oxford, UK.
Neuroradiology. 2025 Aug 25. doi: 10.1007/s00234-025-03744-5.
Derivo embolization device (DED) is a second-generation flow diverter (FD) that has been increasingly used in the management of intracranial aneurysms (IAs). DEDs consist of 48 nitinol wires with an inner platinum core and a blue-colored coating of oxides and oxynitrides, which mitigates these FDs' thrombogenicity. This systematic review and meta-analysis evaluate the efficacy and safety of DED in IAs.
On February 25, 2025, a comprehensive search was conducted across PubMed, Embase, Scopus, and Web of Science in accordance with PRISMA guidelines. Studies reporting clinical and radiological outcomes of DED were included.
Thirteen studies involving 1125 patients and 1338 aneurysms were included. The meta-analysis revealed a pooled complete occlusion rate of 83% (95% CI: 79%-87%), an adequate occlusion rate of 92% (95% CI: 84%-97%), and a favorable outcomes rate of 97% (95% CI: 92%-100%). Additionally, the meta-analysis demonstrated a pooled adjuvant coiling rate of 15% (95% CI: 7%-26%), a major ischemic complication rate of 1% (95% CI: 0%-2%), and a major hemorrhagic complication rate of 0% (95% CI: 0%-1%).
The current study's findings revealed that DEDs are associated with promising complete and adequate occlusion rates concurrent with low rates of major ischemic and hemorrhagic complications.
Derivo栓塞装置（DED）是第二代血流导向装置（FD），已越来越多地用于颅内动脉瘤（IA）的治疗。DED由48根镍钛诺丝组成，内部有铂芯，并涂有蓝色氧化物和氮氧化物涂层，可减轻这些FD的血栓形成性。本系统评价和荟萃分析评估了DED治疗IA的有效性和安全性。
2025年2月25日，按照PRISMA指南在PubMed、Embase、Scopus和Web of Science上进行了全面检索。纳入报告DED临床和影像学结果的研究。
纳入13项研究，共1125例患者和1338个动脉瘤。荟萃分析显示，汇总的完全闭塞率为83%（95%CI：79%-87%），充分闭塞率为92%（95%CI：84%-97%），良好结局率为97%（95%CI：92%-100%）。此外，荟萃分析显示，汇总的辅助栓塞率为15%（95%CI：7%-26%），主要缺血性并发症发生率为1%（95%CI：0%-2%），主要出血性并发症发生率为0%（95%CI：0%-1%）。
本研究结果表明，DED具有较高的完全和充分闭塞率，同时主要缺血性和出血性并发症发生率较低。
