Silva Michael A, See Alfred P, Dasenbrock Hormuzdiyar H, Patel Nirav J, Aziz-Sultan Mohammad A
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Neurosurg Focus. 2017 Jun;42(6):E15. doi: 10.3171/2017.3.FOCUS1718.
OBJECTIVE Patients with paraclinoid aneurysms commonly present with visual impairment. They have traditionally been treated with clipping or coiling, but flow diversion (FD) has recently been introduced as an alternative treatment modality. Although there is still initial aneurysm thrombosis, FD is hypothesized to reduce mass effect, which may decompress the optic nerve when treating patients with visually symptomatic paraclinoid aneurysms. The authors performed a meta-analysis to compare vision outcomes following clipping, coiling, or FD of paraclinoid aneurysms in patients who presented with visual impairment. METHODS A systematic literature review was performed using the PubMed and Web of Science databases. Studies published in English between 1980 and 2016 were included if they reported preoperative and postoperative visual function in at least 5 patients with visually symptomatic paraclinoid aneurysms (cavernous segment through ophthalmic segment) treated with clipping, coiling, or FD. Neuroophthalmological assessment was used when reported, but subjective patient reports or objective visual examination findings were also acceptable. RESULTS Thirty-nine studies that included a total of 2458 patients (520 of whom presented with visual symptoms) met the inclusion criteria, including 307 visually symptomatic cases treated with clipping (mean follow-up 26 months), 149 treated with coiling (mean follow-up 17 months), and 64 treated with FD (mean follow-up 11 months). Postoperative vision in these patients was classified as improved, unchanged, or worsened compared with preoperative vision. A pooled analysis showed preoperative visual symptoms in 38% (95% CI 28%-50%) of patients with paraclinoid aneurysms. The authors found that vision improved in 58% (95% CI 48%-68%) of patients after clipping, 49% (95% CI 38%-59%) after coiling, and 71% (95% CI 55%-84%) after FD. Vision worsened in 11% (95% CI 7%-17%) of patients after clipping, 9% (95% CI 2%-18%) after coiling, and 5% (95% CI 0%-20%) after FD. New visual deficits were found in patients with intact baseline vision at a rate of 1% (95% CI 0%-3%) for clipping, 0% (95% CI 0%-2%) for coiling, and 0% (95% CI 0%-2%) for FD. CONCLUSIONS To the authors' knowledge, this is the first meta-analysis to assess vision outcomes after treatment for paraclinoid aneurysms. The authors found that 38% of patients with these aneurysms presented with visual impairment. These data also demonstrated a high rate of visual improvement after FD without a significant difference in the rate of worsened vision or iatrogenic visual impairment compared with clipping and coiling. These findings suggest that FD is an effective option for treatment of visually symptomatic paraclinoid aneurysms.
目的:蝶骨旁动脉瘤患者常出现视力损害。传统上采用夹闭或栓塞治疗,但近年来血流导向(FD)已作为一种替代治疗方式被引入。尽管最初仍有动脉瘤血栓形成,但推测FD可减轻占位效应,在治疗有视力症状的蝶骨旁动脉瘤患者时可能对视神经起到减压作用。作者进行了一项荟萃分析,以比较夹闭、栓塞或FD治疗有视力损害的蝶骨旁动脉瘤患者后的视力转归。 方法:使用PubMed和Web of Science数据库进行系统文献综述。纳入1980年至2016年期间发表的英文研究,这些研究报告了至少5例有视力症状的蝶骨旁动脉瘤(海绵窦段至眼段)患者接受夹闭、栓塞或FD治疗前后的视觉功能。若有报道则采用神经眼科评估,但患者主观报告或客观视觉检查结果也可接受。 结果:39项研究共纳入2458例患者(其中520例有视觉症状)符合纳入标准,包括307例有视力症状的患者接受夹闭治疗(平均随访26个月),149例接受栓塞治疗(平均随访17个月),64例接受FD治疗(平均随访11个月)。与术前视力相比,这些患者术后视力分为改善、不变或恶化。汇总分析显示,38%(95%CI 28%-50%)的蝶骨旁动脉瘤患者术前有视觉症状。作者发现,夹闭治疗后58%(95%CI 48%-68%)的患者视力改善,栓塞治疗后49%(95%CI 38%-59%)的患者视力改善,FD治疗后71%(95%CI 55%-84%)的患者视力改善。夹闭治疗后11%(95%CI 7%-17%)的患者视力恶化,栓塞治疗后9%(95%CI 2%-18%)的患者视力恶化,FD治疗后5%(95%CI 0%-20%)的患者视力恶化。基线视力正常的患者出现新的视觉缺损的发生率,夹闭治疗为1%(95%CI 0%-3%),栓塞治疗为0%(95%CI 0%-2%),FD治疗为0%(95%CI 0%-2%)。 结论:据作者所知,这是第一项评估蝶骨旁动脉瘤治疗后视力转归的荟萃分析。作者发现这些动脉瘤患者中有38%出现视力损害。这些数据还表明,与夹闭和栓塞相比,FD治疗后视力改善率高,视力恶化率或医源性视力损害率无显著差异。这些发现表明,FD是治疗有视力症状的蝶骨旁动脉瘤的有效选择。
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