Lacanilao Jonathan Paul B, Artiaga Jose Carlo M
Department of Ophthalmology and Visual Sciences, Sentro Oftalmologico Jose Rizal, Philippine General Hospital, University of the Philippines Manila, Taft Avenue, 1000, Manila City, Philippines.
International Eye Institute, St Luke's Medical Center Global City, Taguig City, Philippines.
Int Ophthalmol. 2025 Aug 25;45(1):351. doi: 10.1007/s10792-025-03715-y.
BACKGROUND/OBJECTIVES: To determine the proportion of eyes with optical coherence tomography (OCT) features of polypoidal choroidal vasculopathy (PCV) among patients diagnosed as neovascular age-related macular degeneration (nAMD) based on Asia-Pacific Ocular Imaging Society (APOIS) Diagnostic Criteria.
This study was a retrospective cross-sectional review of OCT images. Medical records of treatment-naïve nAMD patients between January 2018 and June 2023 were reviewed. Clinical and demographic profile at presentation was collected. OCT scans were reviewed for presence of APOIS Diagnostic Criteria. Eyes were classified as having PCV features (PCV) based on the presence of ≥ 2 major OCT APOIS diagnostic criteria and then compared with eyes not having these features (non-PCV).
OCT scans of 45 eyes of 38 patients diagnosed with nAMD were analyzed. Mean age was 69.4 years old (range 53-83), 71.1% of patients were female, and 81.6% had unilateral disease. There was no statistically significant difference among clinical and demographic characteristics between PCV and non-PCV groups. Twenty-four eyes (53.3%) had ≥ 2 major APOIS criteria for PCV. Among PCV eyes, sub-RPE ring-like lesion and double-layer sign were the most common major (87.5%) and minor OCT criteria (100%), respectively. Sharp-peaked PED (p < 0.001), sub-RPE ring-like lesion (p < 0.001), en face OCT complex RPE elevation (p = 0.005) and double-layer sign criteria (p = 0.007) were more frequent in the PCV than in the non-PCV group.
More than half of Filipino eyes diagnosed with nAMD fulfill the OCT criteria for PCV. The APOIS PCV Workgroup Criteria helps identify patients who will benefit from additional confirmatory and treatment options.
背景/目的：根据亚太眼成像协会（APOIS）诊断标准，确定在被诊断为新生血管性年龄相关性黄斑变性（nAMD）的患者中，具有息肉状脉络膜血管病变（PCV）光学相干断层扫描（OCT）特征的眼睛比例。
本研究是对OCT图像的回顾性横断面分析。回顾了2018年1月至2023年6月间未经治疗的nAMD患者的病历。收集了就诊时的临床和人口统计学资料。对OCT扫描结果进行评估，以确定是否符合APOIS诊断标准。根据是否存在≥2项主要OCT APOIS诊断标准，将眼睛分为具有PCV特征（PCV）的眼睛，并与不具有这些特征的眼睛（非PCV）进行比较。
分析了38例诊断为nAMD患者的45只眼睛的OCT扫描结果。平均年龄为69.4岁（范围53 - 83岁），71.1%的患者为女性，81.6%为单眼患病。PCV组和非PCV组在临床和人口统计学特征上无统计学显著差异。24只眼睛（53.3%）具有≥2项PCV的主要APOIS标准。在PCV眼中，视网膜色素上皮（RPE）下环状病变和双层征分别是最常见的主要OCT标准（87.5%）和次要OCT标准（100%）。尖锐峰值的视网膜色素上皮脱离（p < 0.001）、RPE下环状病变（p < 0.001）、OCT正面复杂RPE隆起（p = 0.005）和双层征标准（p = 0.007）在PCV组中比非PCV组更常见。
超过一半被诊断为nAMD的菲律宾人眼睛符合PCV的OCT标准。APOIS PCV工作组标准有助于识别将从额外的确诊和治疗选择中获益的患者。
