Corvi Federico, Chandra Shruti, Invernizzi Alessandro, Pace Lucia, Viola Francesco, Sivaprasad Sobha, Staurenghi Giovanni, Cheung Chui Ming Gemmy, Teo Kelvin Yi Chong
Eye Clinic, Department of Biomedical and Clinical Sciences ``Luigi Sacco'', University of Milan, Italy.
National Institute of Health Research Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Am J Ophthalmol. 2022 Feb;234:108-116. doi: 10.1016/j.ajo.2021.08.006. Epub 2021 Aug 24.
Differences in multimodal imaging features between Asian and Caucasian eyes may contribute to our understanding of the etiology of the polypoidal choroidal vasculopathy (PCV). The purpose of this study was to compare the multimodal imaging features of Asian and Caucasian eyes with PCV.
Cross-sectional, retrospective, multicenter, observational case series.
Consecutive treatment-naïve patients diagnosed with PCV based on indocyanine green angiography in accordance with published guidelines. Demographic and multimodal imaging findings based on color fundus photography, spectral domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography were graded.
A total of 250 participants with PCV (128 Asian vs 122 Caucasian participants) were included. Asian participants presented with lower best-corrected visual acuity (mean ± SD: 0.7 ± 0.6 logMAR vs 0.4 ± 0.3 logMAR; P < .001) compared with Caucasian participants. More Asian eyes had subretinal hemorrhage (mean ± SD: 53.9% vs 24.6%; P < .001) and larger areas of hemorrhage (mean ± SD: 7.5 ± 15.2 mm vs 1.3 ± 3.3 mm; P < .001). More Asian eyes had pachyvessels (84.4% vs 28.7%; P < .001), choroidal vascular hyperpermeability (70.3% vs 17.2%; P < .001), and widespread polypoidal lesions (19.5% vs 8.2%; P = .005), and Caucasian eyes had more drusen (79.5% vs 49.2%; P = .02).
Multimodal imaging analysis revealed ethnic differences in disease characteristics of PCV, suggesting pathophysiologic mechanism of the disease vary based on ethnicity.
亚洲人和白种人眼睛的多模态成像特征差异可能有助于我们理解息肉样脉络膜血管病变（PCV）的病因。本研究的目的是比较亚洲人和白种人患有PCV的眼睛的多模态成像特征。
横断面、回顾性、多中心观察性病例系列。
根据已发表的指南，连续纳入未经治疗且基于吲哚菁绿血管造影诊断为PCV的患者。对基于彩色眼底照相、光谱域光学相干断层扫描、荧光素血管造影和吲哚菁绿血管造影的人口统计学和多模态成像结果进行分级。
共纳入250例PCV患者（128例亚洲人，122例白种人）。与白种人参与者相比，亚洲参与者的最佳矫正视力较低（平均值±标准差：0.7±0.6 logMAR vs 0.4±0.3 logMAR；P<.001）。更多亚洲人眼睛有视网膜下出血（平均值±标准差：53.9% vs 24.6%；P<.001）和更大的出血面积（平均值±标准差：7.5±15.2 mm vs 1.3±3.3 mm；P<.001）。更多亚洲人眼睛有厚壁血管（84.4% vs 28.7%；P<.001）、脉络膜血管高渗透性（70.3% vs 17.2%；P<.001）和广泛的息肉样病变（19.5% vs 8.2%；P=.005），而白种人眼睛有更多的玻璃膜疣（79.5% vs 49.2%；P=.02）。
多模态成像分析揭示了PCV疾病特征的种族差异，表明该疾病的病理生理机制因种族而异。
