Edygenova A K, Ismailov B I, Imangalieva N T, Vakhtin Iu B
Eksp Onkol. 1985;7(6):58-63.
Cells of rat rhabdomyosarcoma Ra-2 inoculated intravenously were trapped only in lungs and formed progressively growing monoclonal metastases. The population of clones was sensitive to the sarcolysin treatment (10-30 mg/kg) at all stages of clone formations (from 1 to 14 days). The drug acted by two ways: by the reduction of the number of clones and by the clone growth rate inhibition. Independent variability of both types of the clone sensitivity resulted in the highly heterogeneous response of clone populations to the sarcolysin treatment.
静脉接种的大鼠横纹肌肉瘤Ra-2细胞仅在肺部滞留，并形成逐渐生长的单克隆转移灶。在克隆形成的所有阶段（1至14天），克隆群体对溶肉瘤素治疗（10 - 30mg/kg）敏感。该药物通过两种方式起作用：减少克隆数量和抑制克隆生长速率。两种类型的克隆敏感性的独立变异性导致克隆群体对溶肉瘤素治疗的反应高度异质性。
