Vasil'eva I A, Kaminskaia E V, Zhukovskaia N V, Dil'man V M
Eksp Onkol. 1988;10(2):29-30.
The rats aged 1, 3, 12 and 15 months were intravenously injected with 10,000 of the rhabdomyosarcoma cells. 3 weeks following the injection multiple tumour clones were observed in the lungs of experimental animals, the rats aged 1 and 15 months showing a significantly greater tumour yield than those aged 3 and 12 months. The level of the mitogenic and somatomedin activity increased both in the blood serum and in the lung tissue, the activity varying with the number of tumour clones. Rhabdomyosarcoma cells, probably, synthesize and release growth factors into the blood.
给1、3、12和15月龄的大鼠静脉注射10000个横纹肌肉瘤细胞。注射后3周，在实验动物的肺中观察到多个肿瘤克隆，1和15月龄的大鼠肿瘤发生率明显高于3和12月龄的大鼠。血清和肺组织中促有丝分裂和生长调节素活性水平均升高，活性随肿瘤克隆数量而变化。横纹肌肉瘤细胞可能合成并向血液中释放生长因子。
