He Guang-Ran, Mo Qian, Jia Chun-Sheng
College of Acupuncture-Moxibustion and Tuina, Hebei University of Traditional Chinese Medicine, Shijiazhuang 050200, China.
Hebei Provincial Key Laboratory of Effect Specificity of Acupuncture and Moxibustion Techniques, Shijiazhuang 050091.
Zhen Ci Yan Jiu. 2025 Aug 25;50(8):974-982. doi: 10.13702/j.1000-0607.20240391.
To analyze the characteristics of point prescriptions for acute and chronic urticaria treated with acupuncture using complex network and data mining, so as to provide the basis for acupoint selection and the approaches to clinical treatment of acute and chronic urticaria.
The clinical trials of acupuncture in treatment of urticaria were systematically searched from China National Knowledge Infrastructure (CNKI), VIP database (VIP), Wanfang database (WanFang), SinoMed and PubMed. According to the screening criteria, the "database of acupuncture for acute and chronic urticaria" was established. IBM SPSS Modeler18.0, Cytoscape3.9.0, Origin2021, Gephi0.9.2 and other softwares were used for frequency analysis, association rule analysis and cluster analysis.
A total of 352 articles were included, and 158 acupuncture prescriptions were extracted, involving 76 points. The analysis focused on main acupoints, and the laws of acupoint selection and medications based on syndrome differentiation. The results showed that the meridian with the highest use frequency of acupuncture was the bladder meridian of foot-. The top 6 acupoints with the highest use frequency included Quchi (LI11), Xuehai (SP10), Zusanli (ST36), Sanyinjiao (SP6), Geshu (BL17) and Feishu (BL13). Acupuncture was delivered for urticaria in terms of "syndrome differentiation and treatment" to determine the principle, and acupuncture was combined with medication as the main regimen. Among reinforcing and reducing techniques, the neutral supplementation and drainage method is the most frequently used. In the acupoint and herbal prescriptions for combined acupuncture-medication therapy of chronic urticaria:the 3 strongest acupoint pairings were Quchi (LI11) and Xuehai (SP10), Quchi (LI11) and Zusanli (ST36), and Xuehai (SP10) and Sanyinjiao (SP6). The 3 strongest herb pairs were Jingjie () and Fangfeng (), Gancao () and Fangfeng (), and Danggui () and Fangfeng (). The three strongest herb-acupoint associations were Xuehai (SP10) and Fangfeng (), Quchi (LI11) and Fangfeng (), and Zusanli (ST36) and Fangfeng ().
Acupuncture is commonly combined with medication in treatment of acute and chronic urticaria. The combined therapy can solve the insufficiency presented in treatment with either simple delivery of acupuncture or Chinese herbal medicine, give a full play to the advantages of acupuncture and Chinese medicine, and advance the therapeutic effect.
运用复杂网络和数据挖掘技术分析针刺治疗急慢性荨麻疹的穴位处方特点，为急慢性荨麻疹的穴位选择及临床治疗方法提供依据。
通过中国知网（CNKI）、维普数据库（VIP）、万方数据库（WanFang）、中国生物医学文献数据库（SinoMed）及PubMed系统检索针刺治疗荨麻疹的临床试验。依据筛选标准，建立“急慢性荨麻疹针刺数据库”。运用IBM SPSS Modeler18.0、Cytoscape3.9.0、Origin2021、Gephi0.9.2等软件进行频次分析、关联规则分析及聚类分析。
共纳入352篇文献，提取158个针刺处方，涉及76个穴位。重点分析主穴及辨证选穴与用药规律。结果显示，针刺使用频次最高的经脉为足太阳膀胱经。使用频次最高的前6个穴位依次为曲池（LI11）、血海（SP10）、足三里（ST36）、三阴交（SP6）、膈俞（BL17）、肺俞（BL13）。针刺治疗荨麻疹遵循“辨证论治”原则，以针刺配合药物治疗为主。在补泻手法方面，平补平泻法使用最为频繁。在慢性荨麻疹针药结合治疗的穴位与中药处方中：最强的3组穴位配伍为曲池（LI11）与血海（SP10）、曲池（LI11）与足三里（ST36）、血海（SP10）与三阴交（SP6）。最强的3组中药药对为荆芥（）与防风（）、甘草（）与防风（）、当归（）与防风（）。最强的3组穴药关联为血海（SP10）与防风（）、曲池（LI11）与防风（）、足三里（ST36）与防风（）。
针刺治疗急慢性荨麻疹常与药物联合应用。联合疗法可解决单纯针刺或单纯中药治疗存在的不足，充分发挥针刺与中药的优势，提高治疗效果。
