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Allogeneic stem cell transplantation from variant-carrying family donors leads to long-term engraftment in Telomere Biology Disorders.

作者信息

Güzel Nergis, Schumacher Yannic, Kricheldorf Kim, Vieri Margherita, Kirschner Martin, Gerhard-le Gars Anne-Claire, Panse Jens, Tometten Mareike, Walter Jeanette, Gehrig Andrea, Kunstmann Erdmute, Holthöfer Laura, Schweiger Susann, Wolff Daniel, Kraft Florian, Elbracht Miriam, Kurth Ingo, Brümmendorf Tim H, Meyer Robert, Beier Fabian

机构信息

Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.

出版信息

Blood Cancer J. 2025 Aug 25;15(1):142. doi: 10.1038/s41408-025-01348-z.

DOI:10.1038/s41408-025-01348-z
PMID:40854872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12378191/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3a/12378191/2ad958d7c46e/41408_2025_1348_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3a/12378191/2ad958d7c46e/41408_2025_1348_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3a/12378191/2ad958d7c46e/41408_2025_1348_Fig1_HTML.jpg

相似文献

1
Allogeneic stem cell transplantation from variant-carrying family donors leads to long-term engraftment in Telomere Biology Disorders.来自携带变异体的家族供体的异基因干细胞移植可导致端粒生物学障碍的长期植入。
Blood Cancer J. 2025 Aug 25;15(1):142. doi: 10.1038/s41408-025-01348-z.
2
Bone marrow versus peripheral blood allogeneic haematopoietic stem cell transplantation for haematological malignancies in adults.成人血液系统恶性肿瘤的骨髓与外周血异基因造血干细胞移植
Cochrane Database Syst Rev. 2014 Apr 20;2014(4):CD010189. doi: 10.1002/14651858.CD010189.pub2.
3
Allogeneic Hematopoietic Cell Transplant For Bone Marrow Failure or Myelodysplastic Syndrome in Dyskeratosis Congenita/Telomere Biology Disorders: Single-Center, Single-Arm, Open-Label Trial of Reduced-Intensity Conditioning Without Radiation.先天性角化不良/端粒生物学障碍患者因骨髓衰竭或骨髓增生异常综合征行异基因造血细胞移植：不使用放疗的非清髓性预处理、单中心、单臂、开放标签试验。
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Pilot Study of Donor-Engrafted Clonal Hematopoiesis Evolution and Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation Recipients Using a National Registry.供者嵌合性造血的演变及其在异基因造血细胞移植受者中的临床结局的初步研究：基于国家注册库的研究
Transplant Cell Ther. 2023 Oct;29(10):640.e1-640.e8. doi: 10.1016/j.jtct.2023.07.021. Epub 2023 Jul 28.
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Bone marrow versus peripheral blood allogeneic haematopoietic stem cell transplantation for haematological malignancies in adults.成人血液系统恶性肿瘤的骨髓与外周血异基因造血干细胞移植。
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Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation.供体来源的恶性肿瘤与移植相关并发症：异基因造血干细胞移植中患者及供体遗传学风险
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Increase of interleukin-18 serum levels after engraftment correlates with acute graft-versus-host disease in allogeneic peripheral blood stem cell transplantation.同种异体外周血干细胞移植后植入后白细胞介素-18血清水平升高与急性移植物抗宿主病相关。
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本文引用的文献

1
Inherited Telomere Biology Disorders: Pathophysiology, Clinical Presentation, Diagnostics, and Treatment.遗传性端粒生物学障碍：病理生理学、临床表现、诊断与治疗
Transfus Med Hemother. 2024 Jul 30;51(5):292-309. doi: 10.1159/000540109. eCollection 2024 Oct.
2
Hematopoietic cell transplantation for telomere biology diseases: A retrospective single-center cohort study.基于端粒生物学疾病的造血细胞移植：回顾性单中心队列研究。
Eur J Haematol. 2023 Sep;111(3):423-431. doi: 10.1111/ejh.14023. Epub 2023 Jun 1.
3
Identification of Adult Patients With Classical Dyskeratosis Congenita or Cryptic Telomere Biology Disorder by Telomere Length Screening Using Age-modified Criteria.
使用年龄修正标准通过端粒长度筛查鉴定患有经典先天性角化不良或隐匿性端粒生物学障碍的成年患者。
Hemasphere. 2023 Apr 20;7(5):e874. doi: 10.1097/HS9.0000000000000874. eCollection 2023 May.
4
Management of patients with germline predisposition to haematological malignancies considered for allogeneic blood and marrow transplantation: Best practice consensus guidelines from the UK Cancer Genetics Group (UKCGG), CanGene-CanVar, NHS England Genomic Laboratory Hub (GLH) Haematological Malignancies Working Group and the British Society of Blood and Marrow Transplantation and cellular therapy (BSBMTCT).考虑接受异基因血液和骨髓移植的血液系统恶性肿瘤种系易感性患者的管理：英国癌症遗传学小组（UKCGG）、加拿大基因-加拿大变异（CanGene-CanVar）、英国国家医疗服务体系（NHS）英格兰基因组实验室中心（GLH）血液系统恶性肿瘤工作组以及英国血液和骨髓移植与细胞治疗学会（BSBMTCT）的最佳实践共识指南
Br J Haematol. 2023 Apr;201(1):35-44. doi: 10.1111/bjh.18682. Epub 2023 Feb 14.
5
Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation.供者和相关异基因造血干细胞移植长期存活者中的克隆性造血。
Blood. 2020 Apr 30;135(18):1548-1559. doi: 10.1182/blood.2019003079.
6
Clinical and Molecular Heterogeneity of RTEL1 Deficiency.RTEL1 缺陷的临床与分子异质性
Front Immunol. 2017 May 1;8:449. doi: 10.3389/fimmu.2017.00449. eCollection 2017.
7
Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.通过患有血小板减少症的造血干细胞移植供体来识别家族性骨髓增生异常综合征/急性白血病易感综合征。
Blood. 2012 Dec 20;120(26):5247-9. doi: 10.1182/blood-2012-09-457945.
8
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA.先天性角化不良因端粒酶RNA突变表现为明显后天性再生障碍性贫血的迟发症状。
Lancet. 2003 Nov 15;362(9396):1628-30. doi: 10.1016/S0140-6736(03)14797-6.
9
Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation.血液谱系中加速的端粒缩短仅限于干细胞移植后的第一年。
Blood. 2001 Jan 15;97(2):575-7. doi: 10.1182/blood.v97.2.575.
10
Polyclonal hematopoiesis with variable telomere shortening in human long-term allogeneic marrow graft recipients.人类长期异基因骨髓移植受者中具有可变端粒缩短的多克隆造血。
Blood. 2000 Dec 1;96(12):3991-4.