Usiyevich Abigail, Li Yufan, Sharma Reema, Arbuckle Kenny, Shah Jay, Matikainen-Ankney Bridget A
Behavioral and Systems Neuroscience, Psychology Department, Rutgers University, Busch Campus Psychology Building Room 317, 152 Frelinghuysen Road, Piscataway, NJ, 08854, USA.
Sci Rep. 2025 Aug 25;15(1):31178. doi: 10.1038/s41598-025-16084-4.
24-h cycles regulate activity and feeding behavior, and obesity and metabolic dysfunction may disrupt such rhythms. Here, using a fixed 24-h light-dark cycle, we investigate sex-specific diurnal physical activity patterns in obese and normal weight mice. We observe that feeding behavior aligns with a mid-dark cycle activity peak. Using passive home cage monitoring and operant feeding tasks, we demonstrate that male and female mice exhibit distinct temporal activity profiles, particularly during the late dark cycle. Diet-induced obesity selectively suppressed mid-dark cycle activity, a temporal window linked to peak food-seeking behavior. These findings highlight temporal disruptions to physical activity in a rodent model of diet-induced obesity and offer insights into potential interactions between feeding behavior and 24 physical activity patterns.
24小时循环调节活动和进食行为，肥胖和代谢功能障碍可能会扰乱这种节律。在此，我们使用固定的24小时明暗循环，研究肥胖和正常体重小鼠的性别特异性昼夜身体活动模式。我们观察到进食行为与黑暗周期中期的活动高峰一致。通过被动式笼内监测和操作性进食任务，我们证明雄性和雌性小鼠表现出不同的时间活动特征，尤其是在黑暗周期后期。饮食诱导的肥胖选择性地抑制了黑暗周期中期的活动，这是一个与觅食行为高峰相关的时间窗口。这些发现突出了饮食诱导肥胖的啮齿动物模型中身体活动的时间紊乱，并为进食行为和身体活动模式之间的潜在相互作用提供了见解。
