Zong Yang, Shen Jia, Wang Lei, Wang Lifeng, Chen Yuli, Ge Chenxing, Gu Jianfeng, Hu Qi
Department of General Surgery, Changshu Hospital Affiliated to Soochow University, No.1, Shuyuan Street, Yushan Town, Changshu, Suzhou, 215501, China.
Biochem Genet. 2025 Aug 25. doi: 10.1007/s10528-025-11235-8.
Long non-coding RNAs (lncRNAs) have become an essential factor in gastric cancer (GC) initiation and metastasis. This study is aimed to uncover the functional significance of EBLN3P in GC. In GC, EBLN3P and HMGCS1 was significantly increased. In contrast, miR-141-3p was decreased. Localization assay revealed that EBLN3P primarily localized in the cytoplasm rather than the nucleus. In MKN28 and SGC7901 cells, EBLN3P knockdown suppressed cell proliferation, metastasis and stemness. On the contrary, overexpression of EBLN3P facilitated these cellular processes. The EBLN3P/miR-141-3p/HMGCS1 axis was identified to play crucial functions in GC progression.
长链非编码RNA（lncRNAs）已成为胃癌（GC）发生和转移的一个重要因素。本研究旨在揭示EBLN3P在胃癌中的功能意义。在胃癌中，EBLN3P和HMGCS1显著增加。相反，miR-141-3p减少。定位分析显示，EBLN3P主要定位于细胞质而非细胞核。在MKN28和SGC7901细胞中，EBLN3P敲低抑制细胞增殖、转移和干性。相反，EBLN3P的过表达促进了这些细胞过程。已确定EBLN3P/miR-141-3p/HMGCS1轴在胃癌进展中起关键作用。
