Rubinstein I, Solomon A, Baum G L, Hiss Y
Eur J Respir Dis. 1985 Nov;67(5):335-40.
Chest roentgenograms of 85 Jewish patients with biopsy-proven pulmonary sarcoidosis were reviewed. In 25 cases (29%), the initial chest roentgenogram showed one of the following unusual manifestations: large pulmonary nodules in 11, an acinar pattern in 10, right hilar lymphadenopathy in 3 and a large pericardial effusion in one patient. Diagnostic biopsy specimens were obtained by an open lung biopsy in 13 patients, by anterior mediastinoscopy in 4, by transbronchial lung biopsy in 3, by skin biopsy in 3 and by liver and splenic tissue examination in 2 patients. Complete roentgenographic resolution occurred only in 4 out of 20 patients who were followed for more than two years (20%), but the majority of them (83% - 15 out of 18 symptomatic patients), improved clinically irrespective of corticosteroid administration. One patient died in the course of follow-up from a cause attributed to sarcoidosis (5% - one out of the 20 patients who were followed for more than two years).
对85例经活检证实为肺结节病的犹太患者的胸部X线片进行了回顾。25例（29%）患者的初始胸部X线片显示出以下异常表现之一：11例为肺部大结节，10例为腺泡样改变，3例为右侧肺门淋巴结肿大，1例患者有大量心包积液。13例患者通过开胸肺活检获取诊断性活检标本，4例通过前纵隔镜检查，3例通过经支气管肺活检，3例通过皮肤活检，2例通过肝脏和脾脏组织检查。在随访两年以上的20例患者中，只有4例（20%）胸部X线表现完全消退，但其中大多数患者（83%，即18例有症状患者中的15例），无论是否使用皮质类固醇，临床症状均有改善。1例患者在随访过程中死于结节病相关原因（5%，即随访两年以上的20例患者中的1例）。
