Development. 2025 Aug 15;152(16). doi: 10.1242/dev.205151. Epub 2025 Aug 26.
A GTPase regulatory protein, PXF-1, is required for synapse development through an actin-mediated mechanism in Caenorhabditis elegans. In this work, Salvatore Cherra and colleagues show that two conserved guanine exchange factors are activated downstream of PXF-1 in a signalling pathway that promotes cholinergic synapse formation in C. elegans. To find out more about their work, we spoke to the first author, Reagan Lamb, and the corresponding author, Salvatore Cherra, Assistant Professor, Department of Neuroscience, College of Medicine, University of Kentucky, USA.
一种GTP酶调节蛋白PXF-1,在线虫中通过肌动蛋白介导的机制参与突触发育。在这项研究中,萨尔瓦托雷·切拉及其同事表明,在促进线虫胆碱能突触形成的信号通路中,两个保守的鸟嘌呤交换因子在PXF-1下游被激活。为了进一步了解他们的工作,我们采访了第一作者里根·兰姆以及通讯作者萨尔瓦托雷·切拉,他是美国肯塔基大学医学院神经科学系助理教授。