Song Lin, Lin Dong-Liang, Zhang Zhao-Fen, Wang Zhou, Zong Yuan-Yuan
Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 JingWu Road, Jinan, 250021, Shandong, China.
Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Diagn Pathol. 2025 Aug 26;20(1):98. doi: 10.1186/s13000-025-01698-z.
Solitary fibrous tumor (SFT) is a fibroblastic tumor characterized by a prominent staghorn vasculature and collagen deposition. However, little is known about SFTs with alveolar structures. Herein, we present a case of an alveolar pattern SFT in a 55-year-old woman. The tumor was present in the lumbosacral spinal canal and showed an alveolar architecture composed of ovoid to spindle-shaped cells. Immunohistochemical examination showed that the tumor cells were positive for STAT6 (nuclear expression), CD34, CD99, and Bcl-2, but negative for cytokeratins (CK-pan and AE1/AE3), EMA, GFAP, CD31, progesterone receptor, S-100 protein, and smooth muscle actin. Furthermore, NAB2::STAT6 fusion was detected using DNA-based next-generation sequencing, which established the diagnosis of SFT at a molecular level. The present case expands the morphological categories of SFT.
孤立性纤维瘤（SFT）是一种以显著的鹿角状血管和胶原沉积为特征的纤维母细胞性肿瘤。然而，对于具有肺泡结构的SFT了解甚少。在此，我们报告一例55岁女性的肺泡型SFT病例。肿瘤位于腰骶部椎管，呈现出由卵圆形至梭形细胞组成的肺泡结构。免疫组织化学检查显示肿瘤细胞STAT6（核表达）、CD34、CD99和Bcl-2呈阳性，但细胞角蛋白（泛细胞角蛋白和AE1/AE3）、EMA、GFAP、CD31、孕激素受体、S-100蛋白和平滑肌肌动蛋白呈阴性。此外，通过基于DNA的二代测序检测到NAB2::STAT6融合，在分子水平上确立了SFT的诊断。本病例扩展了SFT的形态学范畴。
