From the Department of Pathology & Laboratory Medicine, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
Arch Pathol Lab Med. 2018 Jun;142(6):761-766. doi: 10.5858/arpa.2016-0570-RS.
Solitary fibrous tumor (SFT) is a unique mesenchymal neoplasm that was originally believed to be of submesothelial origin. Eventually, SFT expanded to include what was previously called hemangiopericytoma in other regions of the body that had similar immunohistochemical and morphologic features. Although most are benign, many studies have tried to identify histologic features that predict which tumors will behave in an aggressive manner. Recently, dedifferentiation has been described in rare cases of SFT and does appear to correlate with a more aggressive clinical course. Dedifferentiated SFT occurs in a similar age range and location as conventional SFT and can resemble multiple different malignant entities. Utilization of ancillary studies and thorough tissue sampling is important to reach the correct diagnosis. The morphologic features, immunohistochemistry, molecular alterations, and prognosis will be discussed.
孤立性纤维瘤（Solitary fibrous tumor，SFT）是一种独特的间叶性肿瘤，最初被认为起源于亚上皮层。最终，SFT 扩展到包括身体其他部位以前被称为血管外皮细胞瘤的肿瘤，这些肿瘤具有相似的免疫组化和形态特征。尽管大多数是良性的，但许多研究试图确定能够预测哪些肿瘤具有侵袭性行为的组织学特征。最近，在罕见的 SFT 病例中描述了去分化现象，并且似乎与更具侵袭性的临床病程相关。去分化型 SFT 发生在与传统 SFT 相似的年龄范围和部位，并且可以类似于多种不同的恶性实体。辅助研究和彻底的组织取样对于做出正确诊断很重要。将讨论形态特征、免疫组化、分子改变和预后。
