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肝细胞癌光动力疗法的研究概况：2012年至2025年的热点与展望

Research landscape of photodynamic therapy for hepatocellular carcinoma: Hotspots and Prospects from 2012 to 2025.

作者信息

Yu Fei, Yin Sihan, Zhu Jiayu, Sun Kewei

机构信息

Department of Hepatology of the First Affiliated Hospital, Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Yuelu District, 300 Xueshi Road, Science & Education Park, Changsha, 410205, Hunan, China.

出版信息

Hereditas. 2025 Aug 26;162(1):174. doi: 10.1186/s41065-025-00509-1.

DOI:10.1186/s41065-025-00509-1
PMID:40859403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12382027/
Abstract

OBJECTIVE: To explore the current status and future development of photodynamic therapy (PDT) for hepatocellular carcinoma (HCC). However, this field lacks a comprehensive bibliometric analysis. This study aims to investigate the research content and hotspots in PDT for liver cancer from 2012 to 2025, and to predict future research directions, providing references for subsequent studies. METHODS: We chose the Web of Science Core Collection (WoSCC) database and retrieved articles published in the field between 2012 and 2025. Bibliometric and visualization analyses were performed using R (version 4.4.1), VOSviewer (version 1.6.19), and CiteSpace (version 6.4. R1). RESULTS: A total of 547 papers were included. We found that the number of publications in this field has steadily increased from 2012 to 2025. China leads with the highest number of publications, followed by the USA, Korea, Germany, and Japan. China has the lowest international co-authorship rate, while Germany and Japan show higher international collaboration rates. The International Journal of Nanomedicine is the most popular journal for publication, whereas Biomaterials ranks first in terms of citations. Our analysis of keywords and the most cited references revealed that current research focuses on the mechanism of PDT-induced apoptosis in HCC, the development of photosensitizers (PSs), nanotechnology-enhanced PDT, and synergistic treatment of HCC with PDT and other therapies. Nanotechnology and multimodal synergistic therapeutic strategies are driving the treatment of HCC. CONCLUSION: PDT, as a therapy for HCC, is expected to become a research hotspot. This paper analyzes PDT's current research for HCC, offering references for future research in related fields.

摘要

目的：探讨光动力疗法（PDT）治疗肝细胞癌（HCC）的现状及未来发展。然而，该领域缺乏全面的文献计量分析。本研究旨在调查2012年至2025年期间肝癌光动力疗法的研究内容和热点，并预测未来的研究方向，为后续研究提供参考。 方法：我们选择了Web of Science核心合集（WoSCC）数据库，并检索了2012年至2025年期间该领域发表的文章。使用R（版本4.4.1）、VOSviewer（版本1.6.19）和CiteSpace（版本6.4.R1）进行文献计量和可视化分析。 结果：共纳入547篇论文。我们发现，从2012年到2025年，该领域的出版物数量稳步增加。中国的出版物数量最多，其次是美国、韩国、德国和日本。中国的国际合著率最低，而德国和日本的国际合作率较高。《国际纳米医学杂志》是最受欢迎的发表期刊，而《生物材料》在被引次数方面排名第一。我们对关键词和被引次数最多的参考文献的分析表明，当前的研究重点是PDT诱导肝癌细胞凋亡的机制、光敏剂（PSs）的开发、纳米技术增强的PDT以及PDT与其他疗法联合治疗肝癌。纳米技术和多模式协同治疗策略正在推动肝癌的治疗。 结论：PDT作为一种肝癌治疗方法，有望成为研究热点。本文分析了PDT目前对肝癌的研究情况，为相关领域的未来研究提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/a0bbff196c93/41065_2025_509_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/3add632f73ec/41065_2025_509_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/1c38bda0837f/41065_2025_509_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/557984833268/41065_2025_509_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/bea283c73387/41065_2025_509_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/24dcd831e4b8/41065_2025_509_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/11ab980a87c9/41065_2025_509_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/7bfcda59f96d/41065_2025_509_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/a0bbff196c93/41065_2025_509_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/3add632f73ec/41065_2025_509_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/1c38bda0837f/41065_2025_509_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/557984833268/41065_2025_509_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/bea283c73387/41065_2025_509_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/24dcd831e4b8/41065_2025_509_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/11ab980a87c9/41065_2025_509_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/7bfcda59f96d/41065_2025_509_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdea/12382027/a0bbff196c93/41065_2025_509_Fig8_HTML.jpg

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本文引用的文献

[1]
Synergistic Cytotoxicity of Nano-titanium Dioxide and Phthalocyanine on HepG2 Cells via Sonophotodynamic Therapy.

Biol Trace Elem Res. 2025-5-14

[2]
Dual-miRNA guided in-vivo imaging and multimodal nanomedicine approaches for precise hepatocellular carcinoma differentiation and synergistic cancer theranostics using DNA hairpins and dual-ligand functionalized zirconium-MOF nanohybrids.

Biomaterials. 2025-10

[3]
Hepatocellular carcinoma: what are the differential costs compared to the general population?

J Med Econ. 2025-12

[4]
Conversion therapy strategy: A novel GPC3-targeted multimodal organic phototheranostics platform for mid-late-stage hepatocellular carcinoma.

Mater Today Bio. 2025-1-2

[5]
Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy.

Photodiagnosis Photodyn Ther. 2025-2

[6]
EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma.

J Hepatol. 2025-2

[7]
Efficacy of photodynamic therapy using hematoporphyrin derivative nanomedicine on hepatocellular carcinoma cells.

J Cancer. 2024-9-3

[8]
Bibliometric and visual analysis in the field of two-dimensions nano black phosphorus in cancer from 2015 to 2023.

Discov Oncol. 2024-7-3

[9]
Microneedle combined with iontophoresis and electroporation for assisted transdermal delivery of goniothalamus macrophyllus for enhancement sonophotodynamic activated cancer therapy.

Sci Rep. 2024-4-4

[10]
Bibliometric and visual analysis in the field of tea in cancer from 2013 to 2023.

Front Oncol. 2024-1-11

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