Konno Satoshi, Taguri Masataka, Odajima Hiroshi, Minami Mihoko, Takebayashi Toru, Nitta Hiroshi, Nishimura Masaharu
Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Department of Health Data Science, Tokyo Medical University, Shinjuku-ku, Japan.
Physiol Rep. 2025 Aug;13(16):e70508. doi: 10.14814/phy2.70508.
The peripubertal growth pattern of lung function remains underexplored in relation to height growth. This study aimed to first clarify the relationship between the age at peak growth velocity in lung function variables and the age at peak height velocity (APHV) and second identify sex differences in lung function growth patterns. Lung function and height were measured annually in children aged 9-15 years (elementary schools, N = 1307; junior high schools, N = 792) from 2011 to 2018. Children were categorized quarterly according to APHV, using the Super Imposition by Translation and Rotation model. The age at peak growth velocity for forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV) lagged behind APHV by 2-12 months. The later the APHV, the greater the numerical lag, although this was not significant. In males, but not females, the trajectory of FEV/FVC values gradually decreased to reach the lowest levels and then gradually increased with age (U-shaped curve) in all quartiles. Both FVC and FEV overwhelmed in males compared with those in females when the height exceeded 150-160 cm. Our results highlight significant variability in peripubertal lung growth with height and sex-related differences in the growth of airways and parenchymal components.
与身高增长相关的青春期前肺功能生长模式仍未得到充分研究。本研究旨在首先阐明肺功能变量的峰值生长速度年龄与身高峰值速度年龄（APHV）之间的关系，其次确定肺功能生长模式中的性别差异。2011年至2018年，对9至15岁的儿童（小学，N = 1307；初中，N = 792）每年进行肺功能和身高测量。使用平移和旋转叠加模型，根据APHV将儿童按季度分类。用力肺活量（FVC）和1秒用力呼气量（FEV）的峰值生长速度年龄比APHV落后2至12个月。APHV越晚，数值滞后越大，尽管这并不显著。在男性中，而不是女性中，所有四分位数的FEV/FVC值轨迹逐渐下降至最低水平，然后随年龄逐渐增加（U形曲线）。当身高超过150至160厘米时，男性的FVC和FEV均高于女性。我们的研究结果突出了青春期前肺生长随身高的显著变异性以及气道和实质成分生长中的性别相关差异。
