Hauser H, Gandelman R
Horm Behav. 1985 Dec;19(4):454-68. doi: 10.1016/0018-506x(85)90041-8.
Five experiments were performed to determine the extent to which hormones influence maternal behavior of the female mouse. The number of pup-reinforced lever presses served as the measure of maternal behavior. In Experiment 1 it was found that postpartum mice performed significantly more pup-reinforced lever presses than intact or ovariectomized virgins. The second experiment showed that the augmentation of responding was unique to the postpartum period since responding was not facilitated during the last three days of pregnancy. Experiment 3 established that the postpartum augmentation of responding was mediated by the termination of pregnancy and not by parturition per se. It also was observed that the earlier during gestation pregnancy was terminated the greater the decline in response rate. Experiment 4 proved that ovarian secretions play a critical role in the pregnancy-terminated facilitation of pup-reinforced lever pressing. The final experiment demonstrated that the termination-of-pregnancy effect on responding in all likelihood is mediated by the synergistic actions of estrogen stimulation and progesterone withdrawal. The results show that the maternal behavior of the mouse, like that of the rat, is responsive to hormonal stimulation.
进行了五项实验以确定激素对雌性小鼠母性行为的影响程度。幼崽强化杠杆按压的次数作为母性行为的衡量指标。在实验1中发现，产后小鼠进行的幼崽强化杠杆按压显著多于未生育或卵巢切除的处女鼠。第二个实验表明，反应增强是产后时期所特有的，因为在怀孕的最后三天反应并未得到促进。实验3确定，产后反应增强是由妊娠终止介导的，而非分娩本身。还观察到，妊娠终止得越早，反应率下降得越大。实验4证明，卵巢分泌物在妊娠终止后对幼崽强化杠杆按压的促进作用中起关键作用。最后一个实验表明，妊娠终止对反应的影响很可能是由雌激素刺激和孕酮撤退的协同作用介导的。结果表明，小鼠的母性行为与大鼠一样，对激素刺激有反应。
