文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

甲基化介导的长链非编码RNA CRAT40通过招募YBX1启动RelA转录促进结直肠癌进展。

Methylation-mediated LncRNA CRAT40 promotes colorectal cancer progression by recruiting YBX1 to initiate RelA transcription.

作者信息

Lu Qing, Lv Xiuhe, Wang Jin, Xia Bihan, Yan Hailin, Wang Zhu, Yang Jinlin

机构信息

Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

Department of Gastroenterology and Hepatology, Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

出版信息

Int J Biol Sci. 2025 Jul 25;21(11):4834-4850. doi: 10.7150/ijbs.105629. eCollection 2025.

DOI:10.7150/ijbs.105629
PMID:40860198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12374820/
Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in the initiation and progression of various malignancies, including CRC. In this study, we found that lnc-CRAT40 was upregulated in CRC and associated with poor prognosis following CRC resection. Functional assays revealed that elevated lnc-CRAT40 expression promotes tumor cell proliferation and metastasis both in vitro and in vivo. The modification of N6-methyladenosine, driven by METTL3, was essential for the stability of lnc-CRAT40, which may partially contribute to the upregulation of lnc-CRAT40. Mechanistically, lnc-CRAT40 directly interacted with Y-box binding protein 1 (YBX1) and recruits it to the RelA promoter, thereby activating NF-κB signaling, which in turn drives CRC proliferation and metastatic potential. These findings provide novel insights into the molecular mechanisms underlying CRC progression and highlight lnc-CRAT40 as a potential prognostic biomarker and therapeutic target.

摘要

结直肠癌（CRC）仍然是全球癌症相关死亡的主要原因。长链非编码RNA（lncRNAs）已成为包括CRC在内的各种恶性肿瘤发生和发展的关键调节因子。在本研究中，我们发现lnc-CRAT40在CRC中上调，且与CRC切除术后的不良预后相关。功能分析表明，lnc-CRAT40表达升高在体外和体内均促进肿瘤细胞增殖和转移。由METTL3驱动的N6-甲基腺苷修饰对于lnc-CRAT40的稳定性至关重要，这可能部分导致lnc-CRAT40的上调。机制上，lnc-CRAT40直接与Y盒结合蛋白1（YBX1）相互作用，并将其招募到RelA启动子，从而激活NF-κB信号通路，进而驱动CRC的增殖和转移潜能。这些发现为CRC进展的分子机制提供了新的见解，并突出了lnc-CRAT40作为潜在的预后生物标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/18606d327479/ijbsv21p4834g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/a437718add01/ijbsv21p4834g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/582e86bf7a0c/ijbsv21p4834g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/9d019a08765d/ijbsv21p4834g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/8c827f7ea761/ijbsv21p4834g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/2bfe63017521/ijbsv21p4834g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/140fbd91bbc6/ijbsv21p4834g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/7c091088d12f/ijbsv21p4834g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/18606d327479/ijbsv21p4834g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/a437718add01/ijbsv21p4834g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/582e86bf7a0c/ijbsv21p4834g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/9d019a08765d/ijbsv21p4834g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/8c827f7ea761/ijbsv21p4834g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/2bfe63017521/ijbsv21p4834g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/140fbd91bbc6/ijbsv21p4834g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/7c091088d12f/ijbsv21p4834g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/308e/12374820/18606d327479/ijbsv21p4834g008.jpg

相似文献

[1]
Methylation-mediated LncRNA CRAT40 promotes colorectal cancer progression by recruiting YBX1 to initiate RelA transcription.

Int J Biol Sci. 2025-7-25

[2]
Long non-coding RNA PRSS23-AS1 as ceRNA promotes breast cancer progression by regulating EMT via miR-3176 /YBX1 axis.

Cancer Gene Ther. 2025-7-24

[3]
TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification.

Cell Death Dis. 2025-8-16

[4]
Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway.

Cell Mol Biol Lett. 2025-7-21

[5]
The landscape of long non-coding RNA during cSCC progression.

Br J Dermatol. 2025-3-27

[6]
NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through mC methylation.

Breast Cancer Res. 2024-6-6

[7]
PLIN2 promotes colorectal cancer progression through CD36-mediated epithelial-mesenchymal transition.

Cell Death Dis. 2025-7-10

[8]
Steroid receptor coactivator-1 facilitates METTL3-mediated m6A modification by coactivating NF-κB and promotes the malignant progression of glioblastoma.

Oncogene. 2025-7-15

[9]
The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer and promotes metastasis by EMT pathway.

J Cancer Res Clin Oncol. 2017-1

[10]
Long non-coding RNA LNC-POTEM-4 promotes HCC progression via the LNC-POTEM-4/miR-149-5p/Wnt4 signaling axis.

Cell Signal. 2024-12

本文引用的文献

[1]
Review of METTL3 in colorectal cancer: From mechanisms to the therapeutic potential.

Int J Biol Macromol. 2024-10

[2]
A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis.

J Exp Clin Cancer Res. 2024-7-4

[3]
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation.

Mol Cancer. 2024-4-4

[4]
The mA modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN.

Mol Cancer. 2024-3-16

[5]
NF-κB in biology and targeted therapy: new insights and translational implications.

Signal Transduct Target Ther. 2024-3-4

[6]
Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer.

Drug Resist Updat. 2024-3

[7]
Y-Box Binding Protein 1: Unraveling the Multifaceted Role in Cancer Development and Therapeutic Potential.

Int J Mol Sci. 2024-1-5

[8]
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance.

Nat Rev Mol Cell Biol. 2024-5

[9]
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation.

Cell Mol Immunol. 2024-1

[10]
Promotion of colorectal cancer progression by immune-related lnc-SOX9-4 via suppression of YBX1 poly-ubiquitination and degradation.

Cell Signal. 2023-11

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索