Azevedo Filho Fernando Antonio Silva de, Blunck Roberta Muniz, Ali Abdouni Y, Fucs Patrícia Maria de Moraes Barros, Cotias Ricardo Britto
Hospital do Subúrbio, Salvador, Bahia, Brazil.
Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brazil.
Rev Bras Ortop (Sao Paulo). 2025 Aug 25;60(3):1-7. doi: 10.1055/s-0045-1810402. eCollection 2025 Jun.
To evaluate the effect of vitamin C in preventing complex regional pain syndrome (CRPS) in patients with fracture of the distal end of the radius (FDER).
The present study included FDER patients with an indication for surgical treatment and aged over 18 years. We evaluated the age group, gender, dominant side, presence of comorbidities, affected side, trauma mechanism, and the surgical technique. Participants were randomized into 2 groups: placebo ( = 64), which received microcrystalline cellulose, and intervention ( = 58), treated with 1 g/day of vitamin C in a single dose for 60 days, starting immediately after surgery.
The average incidence of neuropathic pain was 17% higher in the placebo group than in the vitamin C one during the evaluation period ( = 0.008). The average visual analog scale (VAS) for pain was 1.22 points higher in the placebo group regardless of evaluation moment ( = 0.001). The CRPS at 12 and 24 weeks were statistically more frequent in the placebo group ( = 0.014 and 0.007, respectively).
Vitamin C has an effect on preventing neuropathic pain and CRPS, as well as on controlling postoperative pain control.
评估维生素C对桡骨远端骨折（FDER）患者预防复杂性区域疼痛综合征（CRPS）的效果。
本研究纳入有手术治疗指征且年龄超过18岁的FDER患者。我们评估了年龄组、性别、优势侧、合并症的存在情况、患侧、创伤机制和手术技术。参与者被随机分为两组：安慰剂组（n = 64），服用微晶纤维素；干预组（n = 58），术后立即开始每天单剂量服用1克维生素C，持续60天。
在评估期间，安慰剂组的神经性疼痛平均发生率比维生素C组高17%（P = 0.008）。无论评估时间点如何，安慰剂组的疼痛平均视觉模拟量表（VAS）得分高1.22分（P = 0.001）。安慰剂组在12周和24周时CRPS的发生率在统计学上更高（分别为P = 0.014和0.007）。
维生素C对预防神经性疼痛和CRPS以及控制术后疼痛有作用。
