Department of Orthopaedic Surgery, University of Southern California Los Angeles, Los Angeles, California, USA.
J Orthop Res. 2021 Apr;39(4):698-706. doi: 10.1002/jor.24947. Epub 2021 Jan 4.
Vitamin C (ascorbic acid), is an important antioxidant that has been applied broadly in the field of orthopaedics. Current research on vitamin C examines the molecule's role in bone and tendon physiology, as well as joint replacement and Postoperative pain. Most laboratory and human studies associate the use of vitamin C with improved bone health and tendon healing. Recent literature moderately supports the use of vitamin C to improve functional outcomes, decreased postoperative pain, and prevent complex regional pain syndrome following orthopaedic procedures. The perioperative use of vitamin C in patients undergoing joint replacement surgery and anterior cruciate ligament reconstruction is still under investigation. Overall, there is need for high-quality human trials to confirm whether vitamin C can potentiate the outcomes of orthopaedic procedures and to determine optimal dosage and means of administration to maximize its proposed benefits. The purpose of this review was to summarize the application of vitamin C in orthopaedic practices and to identify potential areas for future study.
维生素 C（抗坏血酸）是一种重要的抗氧化剂，已广泛应用于骨科领域。目前对维生素 C 的研究主要集中在该分子在骨骼和肌腱生理学、关节置换和术后疼痛方面的作用。大多数实验室和人体研究表明，维生素 C 的使用可以改善骨骼健康和肌腱愈合。最近的文献资料中等程度地支持使用维生素 C 来改善功能结果、减轻术后疼痛并预防骨科手术后的复杂性区域疼痛综合征。在接受关节置换手术和前交叉韧带重建的患者中围手术期使用维生素 C 仍在研究中。总的来说，需要进行高质量的人体试验来证实维生素 C 是否可以增强骨科手术的效果，并确定最佳剂量和给药方式，以最大限度地发挥其预期的益处。本文综述了维生素 C 在骨科实践中的应用，并确定了未来研究的潜在领域。
