血清髓过氧化物酶（MPO）浓度联合甘油三酯-葡萄糖指数（TyG）对冠心病患者主要不良心血管事件（MACE）的预测价值

Predictive value of serum myeloperoxidase (MPO) concentration combined with triglyceride-glucose index (TyG) for major adverse cardiaovascular events (MACE) in patients with coronary heart disease.

作者信息

Wulamu Adila, Li Xiao-Lei, Keremu Munawaer, Ding Shu-Ying, Aizezi Aibibanmu, Li Yan-Peng, Abudukeranmu Gulihuma, Liu Fen, Li Xia, Li Xiao-Mei, Ma Yi-Tong, Adi Dilare, Azhati Adila

机构信息

Emergency Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang, China.

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang, China.

出版信息

Int J Cardiol Cardiovasc Risk Prev. 2025 Aug 10;27:200490. doi: 10.1016/j.ijcrp.2025.200490. eCollection 2025 Dec.

DOI:10.1016/j.ijcrp.2025.200490

PMID:40860315

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12375237/

Abstract

BACKGROUND

Coronary heart disease (CHD) remains a leading cause of mortality globally. The prognostic value of myeloperoxidase (MPO) and the triglyceride-glucose (TyG) index in predicting adverse cardiovascular events among individuals with CHD remains uncertain. This study aimed to investigate the predictive value of MPO in combination with the TyG index for major adverse cardiovascular events (MACE) in patients with CHD.

METHOD

A total of 731 patients with CHD admitted to the First Affiliated Hospital of Xinjiang Medical University between July 2022 and January 2024 were enrolled and analyzed. Patients were categorized based on median values of MPO and the TyG index. Subsequent follow-up was conducted to determine the occurrence of MACE within two years of hospital discharge. Multivariate logistic regression analysis was performed to assess the associations between MPO, the TyG index, and MACE. The area under the receiver operating characteristic (ROC) curve (AUC) was utilized to identify the most valuable predictor. Kaplan-Meier curve analysis was employed to examine the relationship between the predictor and prognosis.

RESULTS

263 patients experienced MACE during a median follow-up of two years. Compared to patients with a lower TyG index (<8.44) and MPO (<417 ng/ml), those with a higher combined TyG index and MPO exhibited the highest risk of MACE. Multivariate logistic regression analysis demonstrated that both the TyG index and MPO level were significant predictors of MACE ( < 0.05), with MPO (Odds Ratio [OR] = 1.01, 95 % Confidence Interval [CI] 1.01-1.01) and the TyG index (OR = 2.80, 95 % CI 1.56-5.00) independently associated with increased MACE risk. Kaplan-Meier curves revealed a higher 2-year overall survival rate in CHD patients with lower serum MPO and TyG index levels. ROC curve analysis showed that the AUC for MACE associated with MPO was 0.71, while the AUC for MACE events linked to the TyG index was 0.67. The combined AUC was 0.71, indicating that MPO enhances the predictive efficacy of the TyG index for MACE in CHD patients ( < 0.05).

CONCLUSION

The TyG index and MPO exhibit a synergistic interaction in increasing the risk of MACE in patients with CHD. These findings underscore the importance of utilizing both measures concurrently when assessing cardiovascular risk in this population.

摘要

背景

冠心病（CHD）仍是全球主要的死亡原因。髓过氧化物酶（MPO）和甘油三酯-葡萄糖（TyG）指数在预测冠心病患者不良心血管事件方面的预后价值仍不确定。本研究旨在探讨MPO联合TyG指数对冠心病患者主要不良心血管事件（MACE）的预测价值。

方法

纳入并分析了2022年7月至2024年1月在新疆医科大学第一附属医院住院的731例冠心病患者。根据MPO和TyG指数的中位数对患者进行分类。随后进行随访，以确定出院后两年内MACE的发生情况。进行多因素逻辑回归分析，以评估MPO、TyG指数与MACE之间的关联。利用受试者工作特征（ROC）曲线下面积（AUC）来确定最有价值的预测指标。采用Kaplan-Meier曲线分析来检验预测指标与预后之间的关系。

结果

在两年的中位随访期内，263例患者发生了MACE。与TyG指数较低（<8.44）且MPO较低（<417 ng/ml）的患者相比，TyG指数和MPO较高的患者发生MACE的风险最高。多因素逻辑回归分析表明，TyG指数和MPO水平均是MACE的显著预测指标（P<0.05），MPO（比值比[OR]=1.01，95%置信区间[CI] 1.01-1.01）和TyG指数（OR=2.80，95% CI 1.56-5.00）与MACE风险增加独立相关。Kaplan-Meier曲线显示，血清MPO和TyG指数水平较低的冠心病患者2年总生存率较高。ROC曲线分析显示，与MPO相关的MACE的AUC为0.71，而与TyG指数相关的MACE事件的AUC为0.67。联合AUC为0.71，表明MPO增强了TyG指数对冠心病患者MACE的预测效能（P<0.05）。