Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai, 200025, China.
Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
BMC Cardiovasc Disord. 2022 Nov 20;22(1):496. doi: 10.1186/s12872-022-02953-7.
The uncontrolled production of MPO promotes inflammation, oxidative stress and atherosclerosis. Serum MPO levels are increased in patients with diabetes compared with patients without diabetes.
This study aimed to investigate whether the serum levels and activities of MPO are related to coronary plaque progression in patients with type 2 diabetes mellitus (T2DM).
Serum MPO levels and activities were measured in 161 patients with diabetes with plaque progression (plaque progression group) and 87 patients with diabetes with no plaque progression (no plaque progression group). These patients were eligible based on the inclusion criteria and received quantitative coronary angiography at baseline and after approximately 1 year of follow-up. The characteristics and parameters of the participants at baseline were documented.
Serum MPO levels and activities were significantly higher in plaque progression group than in no plaque progression group (P < 0.001). We categorized these patients with diabetes into MPO level or activity tertile subgroups. Significant differences in the plaque progression ratio and prominent changes in the minimal lumen diameter, stenosis diameter and coronary artery stenosis score were observed across the tertile subgroups of MPO levels and activities (all P < 0.01). Moreover, serum MPO levels and activities correlated significantly with these indices of coronary artery disease severity after adjustment for other risk factors. Multivariable regression analyses revealed that serum MPO levels and activities remained independently associated with plaque progression, in addition to smoking, hypertension and CRP levels (all P < 0.05).
Serum MPO levels and activities are significantly associated with coronary atherosclerotic plaque progression in patients with type 2 diabetes.
髓过氧化物酶（MPO）的失控产生会促进炎症、氧化应激和动脉粥样硬化。与无糖尿病患者相比，糖尿病患者的血清 MPO 水平升高。
本研究旨在探讨 2 型糖尿病（T2DM）患者的血清 MPO 水平和活性是否与冠状动脉斑块进展有关。
本研究纳入了 161 例有斑块进展的糖尿病患者（斑块进展组）和 87 例无斑块进展的糖尿病患者（无斑块进展组），检测了他们的血清 MPO 水平和活性。这些患者符合纳入标准，在基线和大约 1 年的随访后接受了定量冠状动脉造影检查。记录了参与者的基线特征和参数。
斑块进展组的血清 MPO 水平和活性显著高于无斑块进展组（P<0.001）。我们将这些糖尿病患者分为 MPO 水平或活性三分位亚组。MPO 水平和活性三分位亚组之间的斑块进展率以及最小管腔直径、狭窄直径和冠状动脉狭窄评分的显著变化存在差异（所有 P<0.01）。此外，在调整其他危险因素后，血清 MPO 水平和活性与冠状动脉疾病严重程度的这些指标仍显著相关。多变量回归分析显示，除了吸烟、高血压和 CRP 水平外，血清 MPO 水平和活性与斑块进展独立相关（均 P<0.05）。
血清 MPO 水平和活性与 2 型糖尿病患者的冠状动脉粥样硬化斑块进展显著相关。
