Suzuki Tatsuro, Furuta Hiromi, Naganawa Misa, Hayashi Keiko, Kiyotoshi Hiroko, Ohta Chiharu, Ninomiya Shigemitsu
Department of Respiratory Medicine Toyokawa City Hospital Toyokawa City Japan.
Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences Nagoya City Japan.
Respirol Case Rep. 2025 Aug 21;13(8):e70274. doi: 10.1002/rcr2.70274. eCollection 2025 Aug.
Coronavirus disease 2019 (COVID-19) has resulted in global morbidity, mortality, and societal disruption. COVID-19 mRNA vaccination was mandatory in many countries for a period; however, severe adverse events have been observed in some individuals who received the vaccine. We report a case of COVID-19 mRNA vaccine-induced pneumonitis in a male patient whose cytokine levels were analysed prior to admission. His serum IgE level was high (347 U/mL), and several cytokines were elevated: TNFα was 1.2 pg/mL, IL-6 was 156 pg/mL, and IL-8 was 75.0 pg/mL. The patient developed severe respiratory failure requiring ventilatory support but recovered after steroid pulse therapy.
2019冠状病毒病（COVID-19）已导致全球发病、死亡和社会混乱。在许多国家，COVID-19 mRNA疫苗在一段时间内是强制性的；然而，在一些接种该疫苗的个体中观察到了严重不良事件。我们报告了1例男性患者发生COVID-19 mRNA疫苗诱导的肺炎，在入院前对其细胞因子水平进行了分析。他的血清IgE水平较高（347 U/mL），几种细胞因子升高：TNFα为1.2 pg/mL，IL-6为156 pg/mL，IL-8为75.0 pg/mL。该患者出现严重呼吸衰竭，需要通气支持，但在接受类固醇冲击治疗后康复。
