Wu Jinghua, Xiong Haojun, Chen Jinhua, Yang Dengrong, Li Yujing, Wang Jinglai, Chen Jiaoyu, Zhang Ruixia, Zhang Ruiqi, Li Xiwei, Li Feng, Zhang Runnan, Yang Zhi
Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Department of Dermatology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Front Oncol. 2025 Aug 11;15:1506744. doi: 10.3389/fonc.2025.1506744. eCollection 2025.
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by damage to dopaminergic neurons within the substantia nigra region of the midbrain. Melanoma, on the other hand, is a malignant skin tumor formed by the abnormal proliferation of melanocytes, often linked to genetic predisposition and ultraviolet exposure. Emerging evidence confirms a significant association between PD and melanoma, with individuals afflicted with PD displaying a higher susceptibility to melanoma development. The family genes, known for their involvement in PD etiology, emerge as key players in elucidating this intricate relationship. Through a comprehensive review, it becomes evident that different gene mutations exert varied impacts on both PD and melanoma pathogenesis. For instance, mutations in influence α-synuclein aggregation in both PD and melanoma, while mutations modulate autophagy pathways in both PD and melanoma. The roles of and in melanoma warrant further investigation. Additionally, mutations influence mitophagy mechanisms in PD and melanoma, with implications regarding melanoma proliferation through the PI3K/AKT pathway. Therefore, delineating the precise contributions of genes to PD and melanoma pathophysiology holds paramount importance in devising therapeutic strategies for both PD and melanoma.
帕金森病（PD）是一种常见的神经退行性疾病，其特征是中脑黑质区域内的多巴胺能神经元受损。另一方面，黑色素瘤是一种由黑素细胞异常增殖形成的恶性皮肤肿瘤，通常与遗传易感性和紫外线暴露有关。新出现的证据证实了PD与黑色素瘤之间存在显著关联，患有PD的个体患黑色素瘤的易感性更高。以参与PD病因学而闻名的家族基因，成为阐明这种复杂关系的关键因素。通过全面综述，很明显不同的基因突变对PD和黑色素瘤的发病机制有不同的影响。例如， 中的突变在PD和黑色素瘤中都会影响α-突触核蛋白的聚集，而 突变在PD和黑色素瘤中都会调节自噬途径。 和 在黑色素瘤中的作用值得进一步研究。此外， 突变影响PD和黑色素瘤中的线粒体自噬机制，通过PI3K/AKT途径对黑色素瘤增殖有影响。因此，明确 基因对PD和黑色素瘤病理生理学的确切贡献对于设计PD和黑色素瘤的治疗策略至关重要。
