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视神经损伤后视觉通路的顺行性退变:综述

Anterograde degeneration along the visual pathway following optic nerve injury: a review.

作者信息

Chapelle Anne-Catherine

机构信息

Department of Ophthalmology, Central University Hospital of Liège, University of Liège, Liège, Belgium.

出版信息

Front Neurol. 2025 Aug 8;16:1623798. doi: 10.3389/fneur.2025.1623798. eCollection 2025.

DOI:10.3389/fneur.2025.1623798
PMID:40860968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12370706/
Abstract

The aim of this paper is to review anterograde degeneration throughout the anterior visual pathway, particularly in the optic tracts, the lateral geniculate nucleus, the optic radiations and the visual cortex, following optic nerve injury. Both structural and neuroimaging findings are considered in various diseases, such as optic neuritis and glaucoma. Magnetic resonance imaging findings help localize the specific brain regions where these changes can be observed. Furthermore, particular attention is given to the relationship between cortical atrophy and the location of the associated visual field defect.

摘要

本文旨在综述视神经损伤后整个视觉前通路的顺行性退变,尤其是在视束、外侧膝状体、视辐射和视觉皮层中的退变情况。在各种疾病(如视神经炎和青光眼)中,均考虑了结构和神经影像学检查结果。磁共振成像结果有助于定位可观察到这些变化的特定脑区。此外,还特别关注了皮质萎缩与相关视野缺损位置之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/12370706/485fe31cce2e/fneur-16-1623798-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/12370706/485fe31cce2e/fneur-16-1623798-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/12370706/485fe31cce2e/fneur-16-1623798-g001.jpg

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本文引用的文献

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Nonarteritic Anterior Ischemic Optic Neuropathy: Cystic Change in the Inner Nuclear Layer Caused by Edema and Retrograde Maculopathy.非动脉炎性前部缺血性视神经病变:由水肿和逆行性黄斑病变引起的内核层囊性改变
Ophthalmol Sci. 2022 Oct 4;3(1):100230. doi: 10.1016/j.xops.2022.100230. eCollection 2023 Mar.
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Chronic Histological Outcomes of Indirect Traumatic Optic Neuropathy in Adolescent Mice: Persistent Degeneration and Temporally Regulated Glial Responses.青少年小鼠间接创伤性视神经病变的慢性组织学结果:持续变性和时间调节性神经胶质反应。
Cells. 2021 Nov 28;10(12):3343. doi: 10.3390/cells10123343.
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Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: A longitudinal study.
视神经脊髓炎后视神经病变中外侧膝状体核体积的变化:一项纵向研究。
Neuroimage Clin. 2021;30:102608. doi: 10.1016/j.nicl.2021.102608. Epub 2021 Mar 4.
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J Clin Med. 2020 Sep 10;9(9):2914. doi: 10.3390/jcm9092914.
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