住院和非住院炎症性肠病患者合并症的相关因素：一项单中心初步研究。
Factors associated with comorbidity in hospitalized and non-hospitalized inflammatory bowel disease patients: A single-center, preliminary study.
作者信息
Lenti Marco Vincenzo, Brera Alice Silvia, Broglio Giacomo, Bertolino Giampiera, Di Sabatino Antonio, Klersy Catherine, Corazza Gino Roberto
机构信息
Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy.
First Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
出版信息
J Multimorb Comorb. 2025 Aug 20;15:26335565251365040. doi: 10.1177/26335565251365040. eCollection 2025 Jan-Dec.
BACKGROUND
Inflammatory bowel disease (IBD) may be burdened by other comorbid conditions. We herein sought to assess comorbidity in hospitalized and non-hospitalized IBD patients.
METHODS
This was part of the San MAtteo Complexity (SMAC) study (2017-2019). Data of hospitalized IBD patients were compared to gender- and age-matched IBD outpatients in a 2:1 fashion. The association of comorbidity in relation to hospitalization and clinical and socioeconomic factors was assessed.
RESULTS
We included 104 patients, 27 hospitalized (median age 49 years, IQR 32-70) and 77 outpatients (median age 54 years, IQR 37-68). Comorbidity was reported in 63/104 patients (60.6%), of whom 45 (58.5%) non-hospitalized and 18 (66.6%) hospitalized. Patients with comorbidity were older (median 60 years, IQR 44-61 vs median 40 years, IQR 28-50 vs; p<0.001), had a higher Cumulative Illness Rating Scale severity index (median 1.85, IQR 1.5-2.5 vs median 1.31, IQR 1.2-2.5; p=0.002), were more commonly female (37, 60.7% vs 14, 35.0%; p=0.01), frailer (14, 22.2% vs 1, 2.4%; p=0.004), and had a lower educational level (13, 20.6% vs 2, 4.9%; p=0.04). In a bivariable analysis, factors associated to comorbidity were age >65 years (OR 5.30, 95% CI 1.81-15.55; p=0.002), female sex (OR 2.92, 95% CI 1-27-6.71; p=0.012), income <1000€ (OR 3.04, 95% CI 1.09-8.44; p=0.033), schooling <8 years (OR 5.09, 95% CI 1.08-23.96; p=0.039), frailty (OR 12.56, 95% CI 1.48-106.45; p=0.020), and polypharmacy (OR 10.41, 95% CI 1.85-59.38; p=0.008).
CONCLUSION
A high prevalence of comorbidity was found in IBD, possibly related to low socioeconomic status and poor educational level.
背景
炎症性肠病（IBD）可能伴有其他合并症。我们在此旨在评估住院和非住院IBD患者的合并症情况。
方法
这是圣马泰奥复杂性（SMAC）研究（2017 - 2019年）的一部分。将住院IBD患者的数据与按2:1比例匹配的性别和年龄的IBD门诊患者进行比较。评估合并症与住院情况以及临床和社会经济因素的关联。
结果
我们纳入了104例患者，27例住院患者（中位年龄49岁，四分位间距32 - 70岁）和77例门诊患者（中位年龄54岁，四分位间距37 - 68岁）。104例患者中有63例（60.6%）报告有合并症，其中45例（58.5%）非住院患者和18例（66.6%）住院患者。有合并症的患者年龄更大（中位年龄60岁，四分位间距44 - 61岁，而无合并症患者中位年龄40岁，四分位间距28 - 50岁；p<0.001），累积疾病评定量表严重程度指数更高（中位值1.85，四分位间距1.5 - 2.5，而无合并症患者中位值1.31，四分位间距1.2 - 2.5；p = 0.002），女性更常见（37例，60.7%对14例，35.0%；p = 0.01），身体更虚弱（14例，22.2%对1例，2.4%；p = 0.004），教育水平更低（13例，20.6%对2例，4.9%；p = 0.04）。在双变量分析中，与合并症相关的因素有年龄>65岁（比值比5.30，95%置信区间1.81 - 15.55；p = 0.002）、女性（比值比2.92，95%置信区间1.27 - 6.71；p = 0.012）、收入<1000€（比值比3.04，95%置信区间1.09 - 8.44；p = 0.033）、受教育年限<8年（比值比5.09，95%置信区间1.08 - 23.96；p = 0.039）、身体虚弱（比值比12.56，95%置信区间1.48 - 106.45；p = 0.020）和多种药物治疗（比值比10.41，95%置信区间1.85 - 59.38；p = 0.008）。
结论
IBD患者中合并症的患病率较高，可能与社会经济地位低和教育水平差有关。
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