Tennyson T E, Brown W S, Vaziri N D, Jennison J H
Int J Artif Organs. 1985 Sep;8(5):269-76.
Uremia has been associated with a number of neuro-behavioral deficits. In this study, long-latency event-related potentials (ERP's) and the Symbol Digit Modalities Test (SDMT) were used to assess changes in cortical function due to dialysis treatment. Ten chronic renal failure patients, maintained on hemodialysis, were tested. ERP and SDMT measures were taken immediately before and after dialysis. As a control for any practice effects or neurocognitive changes not associated with hemodialysis, the patients were also assessed with the same procedures on a day off dialysis. Significant increases in N2 and P3 amplitude were demonstrated following the dialysis treatment suggesting that a routine hemodialysis treatment increases the intensity of neural activation. Speed of cortical function, as indexed by ERP component latency and the SDMT, was not affected in any consistent manner by dialysis. However, changes during dialysis in the latency of late ERP components were correlated with changes in subject's serum electrolyte levels, indicating that the speed of cortical function is related to blood electrolyte levels. Differences between subjects in the pre-dialysis latency of the P3 component of the ERP was correlated with pre-dialysis levels of calcium and uric acid, as well as with performance on the SDMT.
尿毒症与许多神经行为缺陷有关。在本研究中，使用长潜伏期事件相关电位（ERP）和符号数字模态测验（SDMT）来评估透析治疗引起的皮质功能变化。对10名维持血液透析的慢性肾衰竭患者进行了测试。在透析前后立即进行ERP和SDMT测量。作为对任何练习效应或与血液透析无关的神经认知变化的对照，还在非透析日对患者进行相同程序的评估。透析治疗后N2和P3波幅显著增加，表明常规血液透析治疗增加了神经激活的强度。以ERP成分潜伏期和SDMT为指标的皮质功能速度未受到透析的任何一致影响。然而，透析期间晚期ERP成分潜伏期的变化与受试者血清电解质水平的变化相关，表明皮质功能速度与血液电解质水平有关。ERP的P3成分透析前潜伏期受试者之间的差异与透析前钙和尿酸水平以及SDMT表现相关。
