Zhu Zhengfeng, Peng Ru, Cai Huanhuan
Department of Medical Oncology, JianHu People's Hospital, Jianhu, China.
School of Clinical Medicine, Jiangsu Health Vocational College, Nanjing, China.
Front Immunol. 2025 Aug 8;16:1586784. doi: 10.3389/fimmu.2025.1586784. eCollection 2025.
Nucleoporin 188 (NUP188) is a vital component of the nuclear pore complex that regulates cancer progression, but its role in diagnosis, prognosis, and immunoregulation in pan-cancer remains unclear.
A comprehensive exploration of the value of NUP188 was performed using different platforms and software, including TCGA, HPA, UALCAN, TISIDB, cBioPortal, STRING, GSCALite, cancerSEA databases, and R software. The expression of NUP188 in gastric cancer (GC) was detected by immunohistochemistry. The association between NUP188 and clinicopathologic features was explored, and the predictive value of NUP188 was determined. The effect of NUP188 knockdown on the proliferation, migration, and invasion of GC cells was detected and vivo.
NUP188 was dysregulated in most human cancers compared to normal tissues with great diagnostic accuracy. The NUP188 expression was associated with molecular subtype, pathologic stage, prognosis, cancer status, and genomic heterogeneity in multiple cancer types. NUP188 was also related to the immune subtype and infiltrating levels of immune cells. The protein level of NUP188 was both upregulated in GC tissues, and was related to HP infection, depth of invasion, distant metastasis, TNM stage, and overall survival of GC patients. NUP188 interference restrained the proliferation, migration, and invasion of GC cells, and inhibited the GC growth .
NUP188 plays a potential role in pan-cancer diagnosis and prognosis and may serve as a novel biomarker for tumor immunotherapy.
核孔蛋白188（NUP188）是核孔复合体的重要组成部分，可调节癌症进展，但其在泛癌中的诊断、预后及免疫调节作用仍不清楚。
使用不同平台和软件对NUP188的价值进行全面探索，包括TCGA、HPA、UALCAN、TISIDB、cBioPortal、STRING、GSCALite、cancerSEA数据库及R软件。通过免疫组织化学检测NUP188在胃癌（GC）中的表达。探讨NUP188与临床病理特征的相关性，并确定NUP188的预测价值。检测NUP188敲低对GC细胞增殖、迁移和侵袭的影响，并进行体内实验。
与正常组织相比，NUP188在大多数人类癌症中表达失调，具有较高的诊断准确性。NUP188表达与多种癌症类型的分子亚型、病理分期、预后、癌症状态及基因组异质性相关。NUP188还与免疫亚型及免疫细胞浸润水平有关。NUP188蛋白水平在GC组织中均上调，且与HP感染、浸润深度、远处转移、TNM分期及GC患者的总生存期相关。NUP188干扰可抑制GC细胞的增殖、迁移和侵袭，并抑制GC生长。
NUP188在泛癌诊断和预后中发挥潜在作用，可能作为肿瘤免疫治疗的新型生物标志物。
