阿尔茨海默病药物研发计划（ADSP）中阿尔茨海默病多样性遗传队列的招募与保留（READD - ADSP）：一项识别阿尔茨海默病遗传因素的全球行动。
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP): A global effort to identify genetic factors in Alzheimer's disease.
作者信息
Akinyemi Rufus, Omotoso Olabode, Kamada Lwere, Ndetei David, Cuccaro Michael, Akpalu Albert, Adams Larry D, Sarfo Stephen F, Njamnshi Alfred K, Whitehead Patrice, Okubadejo Njideka, Ramon Mena Pedro, Damasceno Albertino, Williams Scott, Ayele Biniyam, Zenebe Yared, Adokounou Thierry, Ikanga Jean, Boshe Judith, Akinyemi Joshua, Elugbadebo Olufisayo, Obiako Reginald, Wahab Kolawole, Iwuozo Emmanuel, Akinwande Kazeem, Paddick Stella-Marie, Ogunronbi Mayowa, Musyimi Christine, Ibuchim Anyamele, Ogunde Gabriel, Coker Motunrayo, Adeniji Olaleye, Cadmus Eniola, Olalusi Oladotun, Ciesielski Timothy, Nwani Paul, Blanton Susan Halloran, Olowoyo Paul, Ojo Oluwadamilola, Durodoye Rasaq, Osaigbovo Godwin, Nakasujja Noeline, Andrea Mlaki Damas, Ojagbemi Akinsola, Ogbole Godwin, Farombi Temitope, Ogundele Adefolakemi T, Seixas Azizi, Adebusoye Lawrence, Nichols Michelle, Nwazor Ernest O, Osemwegie Nosakhare, Guerchet Maeleen, Rajabli Farid, Olowookere Olufemi, McCauley Jacob L, Arulogun Oyedunni, Seshadri Sudha, Owolabi Mayowa, Tosto Guiseppe, Byrd Goldie, Walker Richard, Reitz Christiane, Bush William, Baiyewu Olusegun, Griswold Anthony J, Kunkle Brian W, Haines Jonathan, Kalaria Rajesh N, Vance Jeffery M, Ogunniyi Adesola, Pericak-Vance Margaret
机构信息
Neuroscience and Ageing Research Unit Institute for Advanced Medical Research & Training College of Medicine University of Ibadan Ibadan Oyo Nigeria.
Center for Genomic and Precision Medicine College of Medicine University of Ibadan Ibadan Oyo Nigeria.
出版信息
Alzheimers Dement (N Y). 2025 Aug 25;11(3):e70148. doi: 10.1002/trc2.70148. eCollection 2025 Jul-Sep.
INTRODUCTION
Alzheimer's disease (AD) remains a major neurocognitive disorder of global health significance. Globalizing ancestral diversity in AD genetics is essential to identify causal variants, improve diagnosis, and enable equitable therapeutic interventions across populations. The Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) initiative addresses this by including African ancestry and Hispanic/Latinx (HL) ancestry populations.
METHODS
READD-ADSP, a case-control study, aims to recruit, evaluate, and retain 13,000 participants: 5000 Indigenous Africans, 4000 African Americans, and 4000 Hispanic/Latinix individuals. In Africa, recruitment involves nine sub-Saharan African countries under the African Dementia Consortium, and with protocols ensuring standardized data collection, phenotype harmonization, culturally informed diagnostic algorithms, and robust community engagement.
RESULTS
Study pparticipants are recruited, ascertained and retained. Blood samples and fractions (DNA, plasma, RNA) are biobanked for genomic, epigenomic, proteomic, and transcriptomic analyses.
DISCUSSION
This study will advance precision ADRD medicine and establish a model for working with diverse global cohorts of brain disorders.
HIGHLIGHTS
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) addresses critical gaps in Alzheimer's Disease and Related Dementias (ADRD) research by including underrepresented groups.The study recruits 13,000 participants of African, African American, and Hispanic/Latinx ancestries.Standardized protocols enable rigorous phenotyping and harmonization across diverse populations.Findings will inform precision medicine and reduce health disparities in ADRD outcomes.
引言
阿尔茨海默病（AD）仍然是一种具有全球健康重要性的主要神经认知障碍。在AD遗传学中使祖先多样性全球化对于识别因果变异、改善诊断以及在不同人群中实现公平的治疗干预至关重要。ADSP中的阿尔茨海默病多样性遗传队列招募与保留（READD-ADSP）倡议通过纳入非洲血统和西班牙裔/拉丁裔（HL）血统人群来解决这一问题。
方法
READD-ADSP是一项病例对照研究，旨在招募、评估和保留13000名参与者：5000名非洲原住民、4000名非裔美国人和4000名西班牙裔/拉丁裔个体。在非洲，招募工作涉及非洲痴呆症联盟下的九个撒哈拉以南非洲国家，并采用确保标准化数据收集、表型协调、文化知情诊断算法以及强大社区参与的方案。
结果
研究参与者已被招募、确定并保留。血液样本及其组分（DNA、血浆、RNA）被存入生物样本库，用于基因组、表观基因组、蛋白质组和转录组分析。
讨论
本研究将推进精准ADRD医学，并建立一个与全球不同脑疾病队列合作的模型。
亮点
ADSP中的阿尔茨海默病多样性遗传队列招募与保留（READD-ADSP）通过纳入代表性不足的群体，解决了阿尔茨海默病及相关痴呆症（ADRD）研究中的关键差距。该研究招募了13000名具有非洲、非裔美国和西班牙裔/拉丁裔血统的参与者。标准化方案能够在不同人群中进行严格的表型分析和协调。研究结果将为精准医学提供信息，并减少ADRD结果中的健康差距。
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