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BCL2重排阴性的CD23+滤泡中心淋巴瘤与慢性淋巴细胞白血病/小淋巴细胞淋巴瘤：一例罕见的双克隆复合淋巴瘤病例

BCL2-Rearrangment-Negative CD23+ Follicle Center Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Rare Case of Biclonal Composite Lymphoma.

作者信息

Qadir Hira, Palathingal Bava Ejas, Gomez-Gelvez Juan, Liu Wei, Inamdar Kedar, Wey Elizabeth, Carey John, Shen Yulei, Kuriakose Philip, Ghosh Sharmila

机构信息

Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, USA.

Hematology and Medical Oncology, Henry Ford Health System, Detroit, USA.

出版信息

Cureus. 2025 Jul 25;17(7):e88727. doi: 10.7759/cureus.88727. eCollection 2025 Jul.

DOI:10.7759/cureus.88727
PMID:40861583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12375284/
Abstract

Composite lymphomas are rare and diagnostically complex, comprising two or more distinct lymphoma subtypes within the same anatomical site and often requiring a comprehensive diagnostic approach. Due to their rarity and varied presentations, further research is needed to better understand their pathogenesis, clonal relationships, and optimal management strategies. This case report highlights an unusual presentation of composite lymphoma involving the coexistence of BCL2-R-negative, CD23-positive follicle center lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).

摘要

复合淋巴瘤罕见且诊断复杂，由同一解剖部位的两种或更多不同淋巴瘤亚型组成，通常需要综合诊断方法。由于其罕见性和表现多样，需要进一步研究以更好地了解其发病机制、克隆关系和最佳管理策略。本病例报告突出了复合淋巴瘤的一种不寻常表现，即BCL2-R阴性、CD23阳性的滤泡中心淋巴瘤与慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）共存。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/c28f5525d8f8/cureus-0017-00000088727-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/102786c74fff/cureus-0017-00000088727-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/196ca9a7c345/cureus-0017-00000088727-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/b99df62f4874/cureus-0017-00000088727-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/3c3306da552a/cureus-0017-00000088727-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/c28f5525d8f8/cureus-0017-00000088727-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/102786c74fff/cureus-0017-00000088727-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/196ca9a7c345/cureus-0017-00000088727-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/b99df62f4874/cureus-0017-00000088727-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/3c3306da552a/cureus-0017-00000088727-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbb6/12375284/c28f5525d8f8/cureus-0017-00000088727-i05.jpg

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本文引用的文献

1
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2
Follicular lymphoma and marginal zone lymphoma: how many diseases?滤泡性淋巴瘤和边缘区淋巴瘤：有多少种疾病？
Virchows Arch. 2023 Jan;482(1):149-162. doi: 10.1007/s00428-022-03432-2. Epub 2022 Nov 17.
3
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.
世界卫生组织血液淋巴肿瘤分类第五版：髓系和组织细胞/树突状肿瘤。
Leukemia. 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. Epub 2022 Jun 22.
4
The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee.成熟淋巴细胞肿瘤国际共识分类：临床咨询委员会报告。
Blood. 2022 Sep 15;140(11):1229-1253. doi: 10.1182/blood.2022015851.
5
Composite follicular lymphoma and classic Hodgkin lymphoma.复合性滤泡性淋巴瘤和经典型霍奇金淋巴瘤。
J Pathol Transl Med. 2022 Jan;56(1):57-60. doi: 10.4132/jptm.2021.10.09. Epub 2021 Nov 16.
6
Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease.滤泡性淋巴瘤 t(14;18)-阴性在遗传学上是一种异质性疾病。
Blood Adv. 2020 Nov 24;4(22):5652-5665. doi: 10.1182/bloodadvances.2020002944.
7
Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases.复合性小淋巴细胞淋巴瘤/慢性淋巴细胞白血病与滤泡性淋巴瘤：6例临床病理研究
Int J Surg Pathol. 2018 Apr;26(2):135-144. doi: 10.1177/1066896917737161. Epub 2017 Oct 26.
8
Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas: a report of two cases.复合慢性淋巴细胞白血病/小淋巴细胞淋巴瘤和滤泡性淋巴瘤是双克隆性淋巴瘤：两例报告。
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A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36.一种独特的t(14;18)阴性结内滤泡性非霍奇金淋巴瘤亚型，其特征为主要呈弥漫性生长模式且染色体区域1p36存在缺失。
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