Necrotizing Fasciitis Treatment With Chlorine Dioxide: A Case Report in an Immunocompromised Patient.

Necrotizing fasciitis is a rapidly progressive bacterial infection of the fascial planes with high morbidity and mortality, especially in immunocompromised patients. We present a case of a 48-year-old male with multiple comorbidities, including decompensated liver cirrhosis, poorly controlled diabetes mellitus, and chronic kidney disease, who developed a perianal abscess complicated by Fournier's gangrene. The case highlights the challenges in managing a complex patient with multiple organ dysfunction and demonstrates the potential therapeutic role of chlorine dioxide in treating severe soft tissue infections. Despite severe thrombocytopenia, coagulopathy, and metabolic derangements, the patient survived following surgical debridement, targeted antimicrobial therapy, innovative treatment with chlorine dioxide, and intensive supportive care. This case illustrates how prompt diagnosis, coordinated multidisciplinary care, and consideration of alternative therapeutic approaches, including chlorine dioxide, can lead to favorable outcomes even in high-risk patients with significant baseline comorbidities.