Alhwarat Buthainah, Sawalha Khalid, Alshaghdali Ibrahim, Moustafa Abdelmoniem, Paydak Hakan
Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.
Cardiovascular Disease, University of Arkansas for Medical Sciences, Little Rock, USA.
Cureus. 2025 Jul 22;17(7):e88550. doi: 10.7759/cureus.88550. eCollection 2025 Jul.
Sinus bradycardia is defined as a heart rate of less than 60 beats per minute (bpm), and it can be attributed to many etiologies, some of which are reversible, including but not limited to acute coronary syndrome, active infections, electrolyte imbalances, hypothyroidism, and medications. We report the case of a 64-year-old man who was admitted to the intensive care unit for the management of status epilepticus, where he developed new-onset, life-threatening sinus bradycardia, requiring placement on support with two inotropic agents (epinephrine and dopamine) due to persistent hemodynamic instability. Cardiology was consulted as a result, and after extensive workup, including review of past medical conditions, laboratory testing, and telemetry review, including that for reversible etiologies, we identified one of the antiepileptic agents on his medication list as the culprit of his sinus bradycardia. This case serves to contribute to existing, very limited, clinical data on its adverse cardiovascular effects.
窦性心动过缓的定义为心率低于每分钟60次（bpm），其可归因于多种病因，其中一些是可逆的，包括但不限于急性冠状动脉综合征、活动性感染、电解质失衡、甲状腺功能减退和药物。我们报告一例64岁男性病例，该患者因癫痫持续状态入住重症监护病房，在那里他出现了新发的、危及生命的窦性心动过缓，由于持续的血流动力学不稳定，需要使用两种血管活性药物（肾上腺素和多巴胺）进行支持治疗。因此心内科会诊，经过广泛检查，包括回顾既往病史、实验室检查和遥测检查，包括对可逆病因的检查，我们确定他用药清单上的一种抗癫痫药物是其窦性心动过缓的罪魁祸首。该病例有助于补充关于其不良心血管影响的现有非常有限的临床数据。
