Koerner F, Niesel P, König H
Int Ophthalmol. 1985 Nov;8(4):261-6. doi: 10.1007/BF00137655.
A 47-year-old patient was legally blind in her only eye for months due to long-lasting ocular hypotension following chronic uveitis and several operations for cataract and secondary glaucoma. With injections of 0.7 to 2.5 cc 1% Healon into the anterior chamber and vitreous cavity at intervals of 2 to 12 months, intraocular pressure levels between 5 and 12 mmHg could be maintained resulting in an improvement of the visual acuity up to 25/100. The treatment has been continued for over 5 years. A positive correlation was found between the volume of injected Healon and the integral of intraocular pressure over time, and between visual acuity and pressure level. Reduced aqueous flow, high trabecular outflow resistance, and a low rate of clearance of Healon from the vitreous cavity is obviously responsible for the long-lasting elevation of low intraocular pressure levels and for the restoration of useful vision.
一名47岁患者因慢性葡萄膜炎以及多次白内障和继发性青光眼手术导致长期眼压过低，其仅有的一只眼睛已法定失明数月。通过每隔2至12个月向前房和玻璃体腔注射0.7至2.5毫升1%的透明质酸钠（Healon），眼压可维持在5至12毫米汞柱之间，视力提高到了25/100。该治疗已持续5年多。研究发现，注射的透明质酸钠体积与眼压随时间的积分之间，以及视力与眼压水平之间存在正相关。房水流量减少、小梁网流出阻力高以及透明质酸钠从玻璃体腔清除的速率低，显然是导致低眼压水平长期升高以及恢复有用视力的原因。
